Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Nilgiris, Ooty, Tamil Nadu, 643001, India.
Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.
Neurochem Int. 2024 Nov;180:105829. doi: 10.1016/j.neuint.2024.105829. Epub 2024 Aug 13.
Neurodegenerative disorders are generally characterized by progressive neuronal loss and cognitive decline, with underlying mechanisms involving oxidative stress, protein aggregation, neuroinflammation, and synaptic dysfunction. Currently, the available treatment options only improve the symptoms of the disease but do not stop disease progression; neurodegeneration. This underscores the urgent need for novel therapeutic strategies targeting multiple neurodegenerative pathways alongside the conventional therapeutic strategies available. Emerging evidence demonstrates that flavones a subgroup of flavonoids found abundantly in various dietary sources, have surfaced as promising candidates for neuroprotection due to their multifaceted pharmacological properties. Flavones possess the potency to modulate these pathophysiological processes through their antioxidant, anti-inflammatory, and neurotrophic activities. Additionally, flavones have been shown to interact with various cellular targets, including receptors and enzymes, to confer neuroprotection. Though there are ample evidence available, the nutraceutical and neuroprotective pharmacodynamics of flavones have not been very well established. Hence, the current review aims to explores the therapeutic potential of flavones as nutraceuticals with neuroprotective effects, focusing on their ability to modulate key pathways implicated in neurodegenerative diseases. The current article also aims to actuate supplementary research into flavones as potential agents for alleviating neurodegeneration and improving patient outcomes in neurodegenerative disorders globally.
神经退行性疾病通常以进行性神经元丧失和认知能力下降为特征，其潜在机制涉及氧化应激、蛋白质聚集、神经炎症和突触功能障碍。目前，可用的治疗选择仅能改善疾病症状，但无法阻止疾病进展——神经退行性病变。这突显了迫切需要针对多种神经退行性途径的新治疗策略，以及现有的常规治疗策略。新出现的证据表明，黄酮类化合物（一种在各种饮食来源中大量存在的黄酮类化合物的亚组）作为神经保护的有前途的候选物出现，这是由于其多方面的药理学特性。黄酮类化合物具有通过其抗氧化、抗炎和神经营养活性来调节这些病理生理过程的能力。此外，黄酮类化合物已被证明与各种细胞靶标相互作用，包括受体和酶，以提供神经保护。尽管有充分的证据，但黄酮类化合物的营养和神经保护药效学尚未得到很好的确立。因此，目前的综述旨在探讨黄酮类化合物作为具有神经保护作用的营养保健品的治疗潜力，重点关注它们调节与神经退行性疾病相关的关键途径的能力。本文还旨在促使对黄酮类化合物作为减轻神经退行性变和改善全球神经退行性疾病患者结局的潜在药物的补充研究。
