Cline J T, Messer L B
Community Dent Oral Epidemiol. 1979 Aug;7(4):206-12. doi: 10.1111/j.1600-0528.1979.tb01217.x.
A clinical trial of 4047 single applications of Nuva Seal placed on the occlusal surfaces of primary molars, permanent first and second molars and premolars by 250 dental students showed that the sealants were not well retained. The sealant was fully retained on 86% of all permanent posterior teeth at 3 months, on 76% at 6 months, 58% at 12 months, 52% at 24 months and 41% at 36 months. At 4 years, complete sealant coverage was shown by 14% of primary molars, 25% of permanent molars and 68% of premolars. Permanent mandibular molars and premolars were superior to permanent maxillary molars and premolars in fully retaining sealants. Following sealant failure, i.e. providing partial coverage or missing, permanent maxillary molars and premolars were more prone to occlusal caries than permanent mandibular molars and premolars. At 4 years, caries was diagnosed in 40% of applications to permanent molars and in 9% of applications to premolars. Twelve instances of caries under apparently intact sealants were seen.
250名牙科学生对4047颗乳牙、恒牙第一和第二磨牙以及前磨牙的咬合面单次应用Nuva Seal进行的一项临床试验表明,窝沟封闭剂的保留情况不佳。在3个月时,所有恒牙后牙中有86%的窝沟封闭剂完全保留,6个月时为76%,12个月时为58%,24个月时为52%,36个月时为41%。在4年时,14%的乳牙、25%的恒牙磨牙和68%的前磨牙显示窝沟封闭剂完全覆盖。在完全保留窝沟封闭剂方面,恒牙下颌磨牙和前磨牙优于恒牙上颌磨牙和前磨牙。在窝沟封闭剂失败后,即提供部分覆盖或缺失时,恒牙上颌磨牙和前磨牙比恒牙下颌磨牙和前磨牙更容易发生咬合面龋。在4年时,恒牙磨牙应用窝沟封闭剂的病例中有40%被诊断为龋齿,前磨牙应用窝沟封闭剂的病例中有9%被诊断为龋齿。观察到12例在明显完整的窝沟封闭剂下发生龋齿的情况。