Venkateshwara Institute of Pharmacy, Department of Pharmacology, Venkateshwara Group of Institutions Jatoli, Meerut, Uttar Pradesh, India.
Department of Pharmacology, College of Pharmacy, Shri Venkateshwara University affiliation, Gajraula, India.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Aug 16;40:e20240021. doi: 10.62958/j.cjap.2024.021.
Nanosponges are one of the most innovative ways to use the newest developments in nanodrugs delivery. Nanosponges can catch drugs that dissolve in water or ones that don't. This work uses statistical design to find the best nanosponges for drugs that don't dissolve easily and make them.
It was looked into how to statistically make the most of the effects of independent factors. The ethyl cellulose ratio and stirring rate were chosen based on how they affected the dependent variables, such as particle size and how well they were trapped. FTIR, SEM, zeta potential, entrapment efficiency, and particle size data were used to test the nanosponges that were made. Using carbopol, the best lot of nanosponges was added to the gel.
Using ethyl cellulose and polyvinyl alcohol as stabilizers in the emulsion liquid diffusion method, it was possible to make drug-loaded nanosponges. It was possible to make the nanosponges composition work better by using Central Composite Design. It has been seen that making drug-filled nanosponges improves stability.
The study showcased the enhanced capacity of a formulation with decreased particle size and high entrapment efficiency to disseminate effectively.
纳米海绵是利用纳米药物输送最新进展的最具创新性的方法之一。纳米海绵可以捕获溶解在水中的药物或不溶解的药物。本工作使用统计设计来寻找最适合不易溶解药物的纳米海绵，并制备它们。
研究了如何在统计学上最大限度地发挥独立因素的影响。根据乙基纤维素比例和搅拌速度对粒径和包封率等因变量的影响，选择了这两个因素。使用傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、zeta 电位、包封效率和粒径数据来测试制备的纳米海绵。使用卡波姆，将最佳批的纳米海绵添加到凝胶中。
使用乙基纤维素和聚乙烯醇作为乳液液滴扩散法中的稳定剂，可以制备载药纳米海绵。通过使用中心复合设计，可以更好地发挥纳米海绵组成的作用。研究表明，制备载药纳米海绵可以提高稳定性。
该研究展示了一种配方的增强能力，其粒径减小，包封效率高，能够有效传播。
