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Novel pathomechanistic insights into lysosomal storage disorders: how neuron-intrinsic cGAS-STING signaling drives disease progression.

作者信息

Frosch Maximilian, Prinz Marco

机构信息

Institute of Neuropathology, University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.

出版信息

Signal Transduct Target Ther. 2024 Aug 16;9(1):203. doi: 10.1038/s41392-024-01901-5.

DOI:10.1038/s41392-024-01901-5
PMID:39147747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11327262/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7a8/11327262/f7929275f390/41392_2024_1901_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7a8/11327262/f7929275f390/41392_2024_1901_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7a8/11327262/f7929275f390/41392_2024_1901_Fig1_HTML.jpg

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本文引用的文献

1
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders.溶酶体功能障碍的先天免疫感应导致多种溶酶体贮积症。
Nat Cell Biol. 2024 Feb;26(2):219-234. doi: 10.1038/s41556-023-01339-x. Epub 2024 Jan 22.
2
cGAS-STING drives ageing-related inflammation and neurodegeneration.cGAS-STING 驱动与衰老相关的炎症和神经退行性变。
Nature. 2023 Aug;620(7973):374-380. doi: 10.1038/s41586-023-06373-1. Epub 2023 Aug 2.
3
Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease.
β-葡糖脑苷脂直接激活小胶质细胞导致神经元吞噬作用加剧戈谢病。
Immunity. 2023 Feb 14;56(2):307-319.e8. doi: 10.1016/j.immuni.2023.01.008. Epub 2023 Feb 2.
4
Lysosomal storage diseases.溶酶体贮积症。
Nat Rev Dis Primers. 2018 Oct 1;4(1):27. doi: 10.1038/s41572-018-0025-4.
5
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice.抑制神经细胞中的基础自噬会在小鼠中引发神经退行性疾病。
Nature. 2006 Jun 15;441(7095):885-9. doi: 10.1038/nature04724. Epub 2006 Apr 19.