Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Echocardiography, Tehran Heart Center, Tehran, Iran.
Int J Cardiovasc Imaging. 2024 Nov;40(11):2261-2269. doi: 10.1007/s10554-024-03217-5. Epub 2024 Aug 16.
Interatrial septum (IAS) could be redundant by abnormal movement with or without aneurysmal bulging. We aimed to determine the prevalence of isolated redundant and aneurysmal IAS motion and their probable relationship with age and presence of patent foramen ovale (PFO) in a large-scale referral center.
A total of 15,288 patients who underwent transthoracic echocardiography (TTE) at Tehran Heart Center were included From March 2019 to March 2021. Contrast echocardiography was conducted on patients with suspected PFO. Data were retrospectively analyzed from our previously established database. The prevalence of aneurysmal and redundant IAS and their relationship with age and PFO presence was evaluated.
Aneurysmal and isolated redundant IAS were present in 4% and 12.4% of the participants, respectively. The aneurysmal group was older, more frequently female and had higher frequency of PFO. The frequency of PFO among patients with aneurysmal IAS was about 14.4% and 5.3% in isolated redundant IAS patients. In both groups, the prevalence of abnormal IAS motion increased across age groups from the youngest to the oldest, while the prevalence of PFO decreased.
In conclusion, the frequency of PFO among patients with aneurysmal IAS was about 2.5 times more than that among patients with isolated redundant IAS and 24 times more than the normal population. The increasing trend observed across the aging group proposes a potential role for age in the pathophysiology of abnormal IAS. Furthermore, the decreasing prevalence of PFO among patients underlies its clinical significance as an important risk factor.
房间隔（IAS）可能因异常运动而变得多余，无论是否伴有动脉瘤样膨出。我们旨在确定在大型转诊中心，孤立性冗余和动脉瘤性 IAS 运动的患病率及其与年龄和卵圆孔未闭（PFO）存在的可能关系。
共纳入 2019 年 3 月至 2021 年 3 月在德黑兰心脏中心接受经胸超声心动图（TTE）检查的 15288 例患者。对疑似 PFO 的患者进行对比超声心动图检查。从我们之前建立的数据库中回顾性分析数据。评估动脉瘤性和孤立性冗余 IAS 的患病率及其与年龄和 PFO 存在的关系。
动脉瘤性和孤立性冗余 IAS 在参与者中的患病率分别为 4%和 12.4%。动脉瘤组年龄较大，女性更为常见，PFO 发生率较高。动脉瘤性 IAS 患者中 PFO 的发生率约为 14.4%，孤立性冗余 IAS 患者中 PFO 的发生率为 5.3%。在这两组中，异常 IAS 运动的患病率随着年龄的增长从最小到最大而增加，而 PFO 的患病率则降低。
总之，动脉瘤性 IAS 患者中 PFO 的频率比孤立性冗余 IAS 患者高 2.5 倍，比正常人群高 24 倍。观察到的随着年龄组的增加而增加的趋势表明，年龄可能在 IAS 异常的病理生理学中起作用。此外，PFO 在患者中的患病率降低强调了其作为重要危险因素的临床意义。
