Max Planck Institute of Biochemistry, Martinsried, Germany.
Methods Mol Biol. 2024;2828:147-157. doi: 10.1007/978-1-0716-4023-4_12.
Normal-sized cells of Dictyostelium build up a front-tail polarity when they respond to a gradient of chemoattractant. To challenge the polarity-generating system, cells are fused to study the chemotactic response of oversized cells that extend multiple fronts toward the source of attractant. An aspect that can be explored in these cells is the relationship of spontaneously generated actin waves to actin reorganization in response to chemoattractant.
当正常大小的盘基网柄菌细胞对化学引诱物梯度做出反应时，它们会建立起前后极性。为了挑战产生极性的系统，人们会将细胞融合，以研究超大细胞的趋化反应，这些细胞会向吸引源延伸多个前端。在这些细胞中可以探索的一个方面是自发产生的肌动蛋白波与肌动蛋白重组之间的关系，以响应化学引诱物。
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