Shanghai Animal Disease Control Center, Shanghai, 20103, China.
Nanjing Agricultural University College of Veterinary Medicine, Nanjing, 210095, China.
Arch Virol. 2024 Aug 15;169(9):177. doi: 10.1007/s00705-024-06093-5.
Our study was designed to investigate the original spectrum of feline respiratory tract infection and to provide a scientific basis for the clinical diagnosis and treatment of feline respiratory infections and for precise prevention and control measures. A total of 400 cats with upper respiratory tract infections from animal hospitals in 12 provinces in China were examined from November 2022 to October 2023 to investigate the epidemiology of feline calicivirus (FCV), feline herpes virus type 1 (FHV-1), influenza A virus (IAV), Mycoplasma felis, Chlamydia felis, and Bordetella bronchiseptica through loop-mediated isothermal amplification (LAMP) with microfluidic chip detection. The results showed that 396 of the 400 samples tested were positive for at least one of these pathogens, with an overall detection rate of 99.00%. The detection rates were as follows: FCV, 36.00% (144/400); M. felis, 34.00% (136/400); FHV-1, 21.50% (86/400); C. felis, 15.75% (63/400); B. b, 13.00% (52/400); IAV, 4.50% (18/400). There were no statistically significant differences in the detection rates of respiratory pathogens between different sexes, ages, seasons, breeds, or regions (P > 0.05). There were 88 mixed infections, giving a total mixed infection rate of 22.00% (88/400). It is worth noting that the detection rate of FCV at different ages and of FHV-1 in different sexes showed significant differences (P < 0.05). The highest rate of FCV infection was found in animals that were 1 to 2 years old, and the rate of FHV-1 infection in male cats was higher than that in female cats. The results showed that the spectrum of feline respiratory pathogens is complex, with diverse epidemiological characteristics and mixed infections, and some differences among different respiratory pathogens were found with regard to the sex, age, and breed of the cat. Studies should be continued to provide a scientific basis for precise prevention and control of feline respiratory diseases.
我们的研究旨在调查猫呼吸道感染的原始谱，并为猫呼吸道感染的临床诊断和治疗以及精确的预防和控制措施提供科学依据。我们从 2022 年 11 月至 2023 年 10 月，对来自中国 12 个省的动物医院的 400 只患有上呼吸道感染的猫进行了检查，通过微流控芯片检测的环介导等温扩增（LAMP），调查了猫杯状病毒（FCV）、猫疱疹病毒 1 型（FHV-1）、甲型流感病毒（IAV）、猫支原体、猫衣原体和支气管败血波氏杆菌的流行病学。结果表明，在 400 个测试样本中，有 396 个至少有一种病原体呈阳性，总检出率为 99.00%。检出率如下：FCV，36.00%（144/400）；猫支原体，34.00%（136/400）；FHV-1，21.50%（86/400）；猫衣原体，15.75%（63/400）；B. bronchiseptica，13.00%（52/400）；IAV，4.50%（18/400）。不同性别、年龄、季节、品种或地区的呼吸道病原体检出率无统计学差异（P>0.05）。共检测到 88 例混合感染，总混合感染率为 22.00%（88/400）。值得注意的是，不同年龄的 FCV 检出率和不同性别的 FHV-1 检出率差异有统计学意义（P<0.05）。FCV 感染率最高的是 1-2 岁的动物，FHV-1 感染率在雄性猫中高于雌性猫。结果表明，猫呼吸道病原体的谱复杂，具有不同的流行病学特征和混合感染，不同呼吸道病原体在猫的性别、年龄和品种方面存在一些差异。应继续开展研究，为猫呼吸道疾病的精确防控提供科学依据。
