Nam Kum Seok, Kim Yeji, Park Geonho, Hwang Kiwook, Kim Minyoung, Chong Jooyeun, Jeon Jooik, Yang Congqi, Lu Yung Hsiang, Paniccia Christian, Choi Jeongwon, Kim Dong Geun, Lee Haeseung, Oh Seung Won, Kim Sanha, Rhyu Jae-Wook, Kang Jiheong, Hyun Jung Keun, Karp Jeffrey M, Lee Yuhan, Yuk Hyunwoo, Park Seongjun
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Department of Anesthesiology, Perioperative, and Pain Medicine, Center for Accelerated Medical Innovation & Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Adv Mater. 2025 Jan;37(1):e2407116. doi: 10.1002/adma.202407116. Epub 2024 Aug 15.
Pressure-sensitive adhesives are widely utilized due to their instant and reversible adhesion to various dry substrates. Though offering intuitive and robust attachment of medical devices on skin, currently available clinical pressure-sensitive adhesives do not attach to internal organs, mainly due to the presence of interfacial water on the tissue surface that acts as a barrier to adhesion. In this work, a pressure-sensitive, repositionable bioadhesive (PSB) that adheres to internal organs by synergistically combining the characteristic viscoelastic properties of pressure-sensitive adhesives and the interfacial behavior of hydrogel bioadhesives, is introduced. Composed of a viscoelastic copolymer, the PSB absorbs interfacial water to enable instant adhesion on wet internal organs, such as the heart and lungs, and removal after use without causing any tissue damage. The PSB's capabilities in diverse on-demand surgical and analytical scenarios including tissue stabilization of soft organs and the integration of bioelectronic devices in rat and porcine models, are demonstrated.
压敏胶粘剂因其能即时且可逆地粘附于各种干燥基材而被广泛应用。尽管目前可用的临床压敏胶粘剂能直观且牢固地将医疗设备附着于皮肤上，但主要由于组织表面存在作为粘附屏障的界面水，它们无法附着于内部器官。在这项工作中，引入了一种压敏、可重新定位的生物胶粘剂（PSB），它通过协同结合压敏胶粘剂的粘弹性特性和水凝胶生物胶粘剂的界面行为来粘附于内部器官。PSB由一种粘弹性共聚物组成，它能吸收界面水，从而在诸如心脏和肺等湿润的内部器官上实现即时粘附，并在使用后移除而不会造成任何组织损伤。展示了PSB在各种按需手术和分析场景中的能力，包括在大鼠和猪模型中对柔软器官的组织稳定以及生物电子设备的集成。
