Diagnostic and Environmental Pathology Laboratory. Department of Pathology, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
J Med Primatol. 2024 Aug;53(4):e12728. doi: 10.1111/jmp.12728.
Oral focal epithelial hyperplasia (FEH) is an uncommon infection affecting humans, chimpanzees, bonobos, and howler monkeys. This study describes 10 cases of free-ranging brown howler monkeys (Alouatta guariba clamitans) diagnosed with FEH and Alouatta guariba Papillomavirus 1 (AgPV 1).
We analyzed demographic characteristics, rescue conditions, clinical and pathological findings, and species-specific behavior factors in these cases. The study assessed the frequency of occurrence and potential contributing factors of FEH and AgPV 1 infection.
The frequency of FEH was 8.13%. Most affected howlers were adult or geriatric males with comorbidities or stressful conditions. Clinical and pathological observations were consistent with AgPV 1 infection. Species-specific behaviors and environmental stressors were identified as contributing factors.
FEH associated with AgPV 1 affected mainly adult or geriatric males with ongoing comorbidities or stressful conditions. Further research is needed to understand these factors for effective management.
口腔局灶性上皮增生（FEH）是一种罕见的感染人类、黑猩猩、倭黑猩猩和吼猴的疾病。本研究描述了 10 例自由放养的褐吼猴（Alouatta guariba clamitans）诊断为 FEH 和 Alouatta guariba 乳头瘤病毒 1（AgPV 1）感染的病例。
我们分析了这些病例的人口统计学特征、救援条件、临床和病理发现以及物种特异性行为因素。该研究评估了 FEH 和 AgPV 1 感染的发生频率和潜在的促成因素。
FEH 的频率为 8.13%。受影响的吼猴主要是成年或老年雄性，伴有合并症或应激状态。临床和病理观察与 AgPV 1 感染一致。物种特异性行为和环境应激源被确定为促成因素。
与 AgPV 1 相关的 FEH 主要影响患有持续合并症或应激状态的成年或老年雄性。需要进一步研究这些因素以进行有效的管理。
