Gao Jing, Shu Jian-Bo, Liu Yang
Department of Neonatology, Longyan Campus, Tianjin Children's Hospital/Tianjin University Children's Hospital, Tianjin 300134, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2024 Aug 15;26(8):879-886. doi: 10.7499/j.issn.1008-8830.2401065.
Neonatal sepsis is a common and severe infectious disease with a high mortality rate. Its pathogenesis is complex, lacks specific manifestations, and has a low positive culture rate, making early diagnosis and personalized treatment still a challenge for clinicians. Epidemiological studies on twins have shown that genetic factors are associated with neonatal sepsis. Gene polymorphisms are closely related to susceptibility, disease development, and prognosis. This article provides a review of gene polymorphisms related to neonatal sepsis, including interleukins, tumor necrosis factor, Toll-like receptors, NOD-like receptors, CD14, triggering receptor expressed on myeloid cells-1, mannose-binding lectin, and other immune proteins, aiming to promote precision medicine for this disease.
新生儿败血症是一种常见且严重的传染病，死亡率很高。其发病机制复杂，缺乏特异性表现，培养阳性率低，使得早期诊断和个性化治疗对临床医生来说仍然是一项挑战。对双胞胎的流行病学研究表明，遗传因素与新生儿败血症有关。基因多态性与易感性、疾病发展及预后密切相关。本文综述了与新生儿败血症相关的基因多态性，包括白细胞介素、肿瘤坏死因子、Toll样受体、NOD样受体、CD14、髓系细胞表达的触发受体-1、甘露糖结合凝集素及其他免疫蛋白，旨在推动针对该疾病的精准医学发展。
