Sheng Mengqiu, Zhang Yu, Hou Tieying
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Science), Guangdong Provincial Institute of Cardiovascular Diseases, Guangzhou 510080, Guangdong, China.
Department of Laboratory, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Science), Guangzhou 510080, Guangdong, China. Corresponding author: Hou Tieying, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 May;33(5):630-632. doi: 10.3760/cma.j.cn121430-20200922-00641.
Sepsis is a clinical syndrome caused by the host reaction disorder induced by infection, which leads to serious organ function damage. Sepsis is a serious disease with high mortality, which is the main reason of death caused by infection. Single nucleotide polymorphisms (SNP) is one of the most common genetic variants in human, and is closely related to the genetic susceptibility, early diagnosis, disease development and prognosis of sepsis. This article makes a review on the relationship between CD14, Toll like receptor (TLR), tumor necrosis factor (TNF), interleukins (IL-1 and IL-6), plasminogen activator inhibitor 1 (PAI-1), angiotensin converting enzyme (ACE) and other gene polymorphisms and genetic susceptibility of sepsis, in order to affect in sepsis on the early prediction, diagnosis, and treatment.
脓毒症是由感染引起的宿主反应紊乱导致的临床综合征，可导致严重的器官功能损害。脓毒症是一种死亡率高的严重疾病，是感染致死的主要原因。单核苷酸多态性（SNP）是人类最常见的基因变异之一，与脓毒症的遗传易感性、早期诊断、疾病发展及预后密切相关。本文就CD14、Toll样受体（TLR）、肿瘤坏死因子（TNF）、白细胞介素（IL-1和IL-6）、纤溶酶原激活物抑制剂1（PAI-1）、血管紧张素转换酶（ACE）等基因多态性与脓毒症遗传易感性的关系进行综述，以期对脓毒症的早期预测、诊断及治疗有所帮助。
