Institut de Génomique Fonctionnelle de Lyon, UMR5242, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, USC1370 Institut National de Recherche pour l'Agriculture, l'alimentation et l'Environnement, 69364 Lyon, France.
Endocrinology. 2024 Jul 26;165(9). doi: 10.1210/endocr/bqae101.
The nuclear receptors of thyroid hormone exert a broad influence on brain development and then on adult brain physiology. However, the cell-autonomous function of the receptors is combined with their indirect influence on cellular interactions. Mouse genetics allows one to distinguish between these 2 modes of action. It revealed that 1 of the main cell-autonomous functions of these receptors is to promote the maturation of GABAergic neurons. This review presents our current understanding of the action of thyroid hormone on this class of neurons, which are the main inhibitory neurons in most brain areas.
甲状腺激素的核受体对大脑发育和成年大脑生理学有广泛的影响。然而，受体的细胞自主功能与它们对细胞间相互作用的间接影响相结合。小鼠遗传学使人们能够区分这两种作用模式。它揭示了这些受体的主要细胞自主功能之一是促进 GABA 能神经元的成熟。这篇综述介绍了我们目前对甲状腺激素对这类神经元的作用的理解，这类神经元是大多数脑区的主要抑制性神经元。
