Chehl S, Job C K, Hastings R C
Am J Trop Med Hyg. 1985 Nov;34(6):1161-6. doi: 10.4269/ajtmh.1985.34.1161.
Nude mice in groups of 10 were exposed to M. leprae by subcutaneous injection and topically through the nose, lungs, mouth, stomach and skin, broken and unbroken. Animals injected subcutaneously and those topically exposed to M. leprae through the nose developed localized disease which in the course of time became generalized. The nose seems to be the site of entry of M. leprae in this model. To the extent that these results can be generalized to humans exposed to M. leprae, it would seem that leprosy bacilli impact topically on the nasal mucosa or are inoculated subcutaneously.
将10只一组的裸鼠通过皮下注射以及经鼻、肺、口腔、胃和完整及破损皮肤局部接触麻风杆菌。皮下注射的动物以及经鼻局部接触麻风杆菌的动物发生了局部疾病，随着时间推移疾病发展为全身性疾病。在这个模型中，鼻子似乎是麻风杆菌的进入部位。就这些结果能够推广到接触麻风杆菌的人类而言，麻风杆菌似乎是局部影响鼻黏膜或通过皮下接种。
