Cheng Heming, Dai Jifeng, Li Gen, Ding Dongfang, Li Jianyun, Zhang Ke, Wei Liuchuang, Hou Jie
Department of Mechanics, Kunming University of Science and Technology, Kunming, China.
Department of Hydraulic Engineering, Kunming University of Science and Technology, Kunming, China.
Front Physiol. 2024 Aug 1;15:1353768. doi: 10.3389/fphys.2024.1353768. eCollection 2024.
Orthostatic hypotension (OH) is common among the older population. The mechanism hypothesized by OH as a risk factor for cognitive decline and dementia is repeated transient cerebral blood flow deficiency. However, to our knowledge, quantitative evaluation of cardiac output and cerebral blood flow due to acute blood pressure changes resulting from postural changes is rare. We report a new fluid-structure interaction model to analyze the quantitative relationship of cerebral blood flow during OH episodes. A device was designed to simulate the aging of blood vessels. The results showed that OH was associated with decreased transient cerebral blood flow. With the arterial aging, lesions, the reduction in cerebral blood flow is accelerated. These findings suggest that systolic blood pressure regulation is more strongly associated with cerebral blood flow than diastolic blood pressure, and that more severe OH carries a greater risk of dementia. The model containing multiple risk factors could apply to analyze and predict for individual patients. This study could explain the hypothesis that transient cerebral blood flow deficiency in recurrent OH is associated with cognitive decline and dementia.
体位性低血压（OH）在老年人群中很常见。OH作为认知能力下降和痴呆症的一个风险因素，其假设机制是反复出现短暂性脑血流量不足。然而，据我们所知，因体位变化导致急性血压变化而对心输出量和脑血流量进行的定量评估很少见。我们报告了一种新的流固耦合模型，以分析OH发作期间脑血流量的定量关系。设计了一种装置来模拟血管老化。结果表明，OH与短暂性脑血流量减少有关。随着动脉老化、病变，脑血流量的减少会加速。这些发现表明，收缩压调节与脑血流量的相关性比舒张压更强，而且更严重的OH患痴呆症的风险更大。包含多个风险因素的模型可用于对个体患者进行分析和预测。本研究可以解释复发性OH中短暂性脑血流量不足与认知能力下降和痴呆症相关的假设。
