Tella Adedibu C, Olatunji Sunday J, Ajibade Peter A
Department of Chemistry, University of Ilorin P.M.B.1515 Ilorin Kwara State Nigeria
School of Chemistry and Physics, University of KwaZulu-Natal Private Bag X01 Scottsville 3209 South Africa.
RSC Adv. 2024 Aug 15;14(35):25759-25770. doi: 10.1039/d4ra03678f. eCollection 2024 Aug 12.
A porous copper(ii) metal-organic framework (MOF) of 4,4',4''-tri--butyl-2,2':6',2''-terpyridine(Nttb) and 5-nitroisophthalic acid (npd) formulated as [Cu(npd)(Nttb)]·(DMF)(HO) 1 (DMF = dimethylformamide) was synthesized and characterized by elemental analyses, spectroscopic techniques, single crystal X-ray crystallography, and scanning electron microscopy. Single crystal X-ray crystallographic analysis of the copper(ii) metal-organic framework reveals a monoclinic crystal system with space group 2/. The copper(ii) ion is in a five-coordinate geometry consisting of three meridional nitrogen atoms of 4,4',4''-tri--butyl-2,2':6',2''-terpyridine and two oxygen atoms of 5-nitroisophthalic acid to form a square pyramidal structure. The compound was functionalized with ethylenediamine (ED) to form [Cu(npd)(Nttb)]-ED 2 that was characterized by FT-IR, PXRD, SEM-EDX and BET and the drug loading capacity was investigated and compared with that of as-synthesized MOFs. The amount of ibuprofen loaded was 916.44 mg g (15.27%) & 1530.20 mg g (25.50%) over 1 and 2, respectively. The results indicate that the functionalized MOFs 2 have a higher loading capacity for ibuprofen than 1 by 613.76 mg g (10.23%), which could be ascribed to the acid-base interactions in the functionalized molecules. The results show that [Cu(npd)(Nttb)]-ED 2 is a better drug transporter than [Cu(npd)(Nttb)]·(DMF)(HO) 1 due to the presence of an amine functional group that interacts with the acid group on the ibuprofen through non-covalent bonds interactions.
合成了一种由4,4',4''-三叔丁基-2,2':6',2''-三联吡啶（Nttb）和5-硝基间苯二甲酸（npd）组成的多孔铜（II）金属有机框架（MOF），其化学式为[Cu(npd)(Nttb)]·(DMF)(H₂O) 1（DMF = 二甲基甲酰胺），并通过元素分析、光谱技术、单晶X射线晶体学和扫描电子显微镜对其进行了表征。铜（II）金属有机框架的单晶X射线晶体学分析揭示了一个空间群为C2/c的单斜晶体系统。铜（II）离子处于五配位几何结构中，由4,4',4''-三叔丁基-2,2':6',2''-三联吡啶的三个经向氮原子和5-硝基间苯二甲酸的两个氧原子组成，形成一个四方锥结构。该化合物用乙二胺（ED）进行功能化，形成[Cu(npd)(Nttb)]-ED 2，并通过傅里叶变换红外光谱（FT-IR）、粉末X射线衍射（PXRD）、扫描电子显微镜-能谱分析（SEM-EDX）和比表面积分析（BET）对其进行了表征，并研究了其药物负载能力，并与合成的MOF进行了比较。布洛芬的负载量分别在1和2上为916.44 mg/g（15.27%）和1530.20 mg/g（25.50%）。结果表明，功能化的MOF 2对布洛芬的负载能力比1高613.76 mg/g（10.23%），这可能归因于功能化分子中的酸碱相互作用。结果表明，[Cu(npd)(Nttb)]-ED 2是一种比[Cu(npd)(Nttb)]·(DMF)(H₂O) 1更好的药物转运体，这是由于存在一个胺官能团，它通过非共价键相互作用与布洛芬上的酸基团相互作用。
