Owensby D A, O'Rourke M F
Aust N Z J Med. 1985 Dec;15(6):704-11.
Pindolol, a beta blocker with intrinsic sympathomimetic activity, was investigated in a randomised controlled trial of 100 patients presenting within 12 hours of uncomplicated acute myocardial infarction. Pindolol was given intravenously for 24 hours and orally for 48 hours to achieve serum levels above 10 ng/ml. Heart rate and arterial pressure, both systolic and diastolic, fell to a similar degree in actively treated and control patients. There was no significant difference between systolic blood pressure-heart rate product in actively treated and control patients during the first 72 hours of therapy. There was no increased incidence of cardiac failure, bradycardia, or AV conduction disturbance among pindolol-treated patients. Infarct size estimated from cumulative enzyme release did not differ significantly from controls regardless of whether pindolol was given within four hours or between four and 12 hours of symptom onset. However, fewer patients given pindolol within four hours required morphine. Use of pindolol during the acute phase of myocardial infarction did not appear to modify clinical course, hemodynamic determinants of myocardial oxygen demand, or enzymatically determined infarct size.
吲哚洛尔是一种具有内在拟交感活性的β受体阻滞剂，在一项针对100例无并发症急性心肌梗死发病12小时内就诊患者的随机对照试验中进行了研究。静脉给予吲哚洛尔24小时，口服48小时，以使血清水平高于10 ng/ml。积极治疗组和对照组患者的心率以及收缩压和舒张压均下降至相似程度。在治疗的前72小时内，积极治疗组和对照组患者的收缩压 - 心率乘积无显著差异。在吲哚洛尔治疗的患者中，心力衰竭、心动过缓或房室传导障碍的发生率没有增加。无论吲哚洛尔是在症状发作后4小时内还是4至12小时之间给予，根据累积酶释放量估计的梗死面积与对照组相比均无显著差异。然而，在4小时内给予吲哚洛尔的患者中，需要使用吗啡的人数较少。在心肌梗死急性期使用吲哚洛尔似乎并未改变临床病程、心肌需氧量的血流动力学决定因素或酶学测定的梗死面积。
