• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

国家层面阿尔茨海默病及相关痴呆症的发病率与ω-6多不饱和脂肪酸摄入量增加有关。

Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption.

作者信息

Ciesielski Timothy H, Tosto Giuseppe, Durodoye Razaq O, Rajabali Farid, Akinyemi Rufus O, Byrd Goldie S, Bush William S, Kunkle Brian W, Reitz Christiane, Vance Jeffery M, Pericak-Vance Margaret A, Haines Jonathan L, Williams Scott M

机构信息

Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, 10900 Euclid Ave. Cleveland, OH 44106.

Taub Institute for Research on Alzheimer Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, 630 West 168th Street New York, NY 10032.

出版信息

medRxiv. 2024 Aug 8:2024.08.07.24311637. doi: 10.1101/2024.08.07.24311637.

DOI:10.1101/2024.08.07.24311637
PMID:39148832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11326357/
Abstract

INTRODUCTION

Clinical and genetic studies have implicated lipid dysfunction in Alzheimer Disease (AD) pathogenesis. However, lipid consumption at the individual-level does not vary greatly within most cohorts, and multiple lipids are rarely measured in any one study.

METHODS

Mean country-level lipid intakes were compared to Age-Standardized Alzheimer-Disease-Incidence-Rates(ASAIR) in 183 countries across all inhabited continents. Penalized spline regression and multivariable-adjusted linear regression, including a lag between intake and incidence, were used to assess the relationships between five lipid intakes and ASAIR. Validation was conducted using longitudinal within-country changes between 1990 and 2019.

RESULTS

Omega6 Polyunsaturated-Fatty-Acid(PUFA) intake exhibited a positive linear relationship with ASAIR(multivariable-adjusted model: β=2.44; 95%CI: 1.70, 3.19; p=1.38×10). ASAIR also increased with saturated-fat, trans-fat, and dietary-cholesterol up to a threshold. The association between Omega6-PUFA and ASAIR was confirmed using longitudinal intake changes.

DISCUSSION

Decreasing Omega6-PUFA consumption on the country-level may have substantial benefits in reducing the country-level burden of AD.

摘要

引言

临床和遗传学研究表明脂质功能障碍与阿尔茨海默病（AD）的发病机制有关。然而，在大多数队列中，个体层面的脂质摄入量变化不大，并且在任何一项研究中很少对多种脂质进行测量。

方法

将所有有人居住大陆的183个国家的国家层面平均脂质摄入量与年龄标准化阿尔茨海默病发病率（ASAIR）进行比较。使用惩罚样条回归和多变量调整线性回归（包括摄入量和发病率之间的滞后）来评估五种脂质摄入量与ASAIR之间的关系。利用1990年至2019年间国家内部的纵向变化进行验证。

结果

ω-6多不饱和脂肪酸（PUFA）摄入量与ASAIR呈正线性关系（多变量调整模型：β=2.44；95%置信区间：1.70，3.19；p=1.38×10）。饱和脂肪、反式脂肪和膳食胆固醇的摄入量在达到阈值之前，ASAIR也会增加。利用纵向摄入量变化证实了ω-6-PUFA与ASAIR之间的关联。

讨论

在国家层面减少ω-6-PUFA的摄入量可能对减轻国家层面的AD负担有很大益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f01/11326357/eee788831a15/nihpp-2024.08.07.24311637v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f01/11326357/eee788831a15/nihpp-2024.08.07.24311637v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f01/11326357/eee788831a15/nihpp-2024.08.07.24311637v1-f0001.jpg

相似文献

1
Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption.国家层面阿尔茨海默病及相关痴呆症的发病率与ω-6多不饱和脂肪酸摄入量增加有关。
medRxiv. 2024 Aug 8:2024.08.07.24311637. doi: 10.1101/2024.08.07.24311637.
2
Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption.国家层面的阿尔茨海默病及相关痴呆症发病率与ω-6多不饱和脂肪酸摄入量增加有关。
Commun Med (Lond). 2025 Jul 31;5(1):326. doi: 10.1038/s43856-025-01059-3.
3
Effects of a gluten-reduced or gluten-free diet for the primary prevention of cardiovascular disease.减少或无麸质饮食对心血管疾病一级预防的影响。
Cochrane Database Syst Rev. 2022 Feb 24;2(2):CD013556. doi: 10.1002/14651858.CD013556.pub2.
4
Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).血浆和脑脊液β淀粉样蛋白用于诊断轻度认知障碍（MCI）患者的阿尔茨海默病性痴呆及其他痴呆。
Cochrane Database Syst Rev. 2014 Jun 10;2014(6):CD008782. doi: 10.1002/14651858.CD008782.pub4.
5
Reduction in saturated fat intake for cardiovascular disease.减少饱和脂肪摄入量以预防心血管疾病。
Cochrane Database Syst Rev. 2015 Jun 10(6):CD011737. doi: 10.1002/14651858.CD011737.
6
CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).脑脊液tau蛋白及脑脊液tau蛋白与β淀粉样蛋白比值在轻度认知障碍（MCI）患者中用于诊断阿尔茨海默病性痴呆及其他痴呆。
Cochrane Database Syst Rev. 2017 Mar 22;3(3):CD010803. doi: 10.1002/14651858.CD010803.pub2.
7
Omega-3 fatty acids for the treatment of dementia.用于治疗痴呆症的欧米伽-3脂肪酸。
Cochrane Database Syst Rev. 2016 Apr 11;4(4):CD009002. doi: 10.1002/14651858.CD009002.pub3.
8
Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.成人全身麻醉后预防术后恶心呕吐的药物：网状Meta分析
Cochrane Database Syst Rev. 2020 Oct 19;10(10):CD012859. doi: 10.1002/14651858.CD012859.pub2.
9
18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).使用氟代硼吡咯进行18F正电子发射断层显像以早期诊断轻度认知障碍（MCI）患者的阿尔茨海默病性痴呆及其他痴呆。
Cochrane Database Syst Rev. 2017 Nov 22;11(11):CD012216. doi: 10.1002/14651858.CD012216.pub2.
10
Polyunsaturated fatty acid supplementation for drug-resistant epilepsy.补充多不饱和脂肪酸治疗耐药性癫痫。
Cochrane Database Syst Rev. 2016 Aug 17;2016(8):CD011014. doi: 10.1002/14651858.CD011014.pub2.

本文引用的文献

1
APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.载脂蛋白 E4/4 与阿尔茨海默病小胶质细胞中的脂滴损伤有关。
Nature. 2024 Apr;628(8006):154-161. doi: 10.1038/s41586-024-07185-7. Epub 2024 Mar 13.
2
Diet's Role in Modifying Risk of Alzheimer's Disease: History and Present Understanding.饮食在改变阿尔茨海默病风险中的作用：历史和现有认识。
J Alzheimers Dis. 2023;96(4):1353-1382. doi: 10.3233/JAD-230418.
3
Time-lagged relationships between a decade of air pollution exposure and first hospitalization with Alzheimer's disease and related dementias.
空气污染暴露十年与首次阿尔茨海默病和相关痴呆症住院之间的时滞关系。
Environ Int. 2023 Jan;171:107694. doi: 10.1016/j.envint.2022.107694. Epub 2022 Dec 12.
4
Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2019.1990 - 2019年全球、区域及国家层面阿尔茨海默病和其他痴呆症的负担
Front Aging Neurosci. 2022 Oct 10;14:937486. doi: 10.3389/fnagi.2022.937486. eCollection 2022.
5
Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer's dementia.载脂蛋白 E4 携带者和阿尔茨海默病患者死后脑组织中类二十烷酸脂质组的激活。
Alzheimers Res Ther. 2022 Oct 11;14(1):152. doi: 10.1186/s13195-022-01084-7.
6
Quality of dietary fat and risk of Alzheimer's disease and dementia in adults aged ≥50 years: a systematic review.膳食脂肪质量与≥50岁成年人患阿尔茨海默病和痴呆症的风险：一项系统综述
Food Nutr Res. 2022 Jul 28;66. doi: 10.29219/fnr.v66.8629. eCollection 2022.
7
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.神经元 ROS 诱导的神经胶质脂滴形成受阿尔茨海默病相关基因缺失的影响。
Proc Natl Acad Sci U S A. 2021 Dec 28;118(52). doi: 10.1073/pnas.2112095118.
8
Epigenomics and Lipidomics Integration in Alzheimer Disease: Pathways Involved in Early Stages.阿尔茨海默病中的表观基因组学与脂质组学整合：早期阶段涉及的途径
Biomedicines. 2021 Dec 2;9(12):1812. doi: 10.3390/biomedicines9121812.
9
Overconsumption of Omega-6 Polyunsaturated Fatty Acids (PUFAs) versus Deficiency of Omega-3 PUFAs in Modern-Day Diets: The Disturbing Factor for Their "Balanced Antagonistic Metabolic Functions" in the Human Body.现代饮食中ω-6多不饱和脂肪酸（PUFAs）摄入过量与ω-3 PUFAs缺乏：人体中其“平衡拮抗代谢功能”的干扰因素
J Lipids. 2021 Mar 17;2021:8848161. doi: 10.1155/2021/8848161. eCollection 2021.
10
Low Omega-3 intake is associated with high rates of depression and preterm birth on the country level.低欧米伽 3 摄入量与国家层面的高抑郁率和早产率有关。
Sci Rep. 2020 Nov 12;10(1):19749. doi: 10.1038/s41598-020-76552-x.