国家层面阿尔茨海默病及相关痴呆症的发病率与ω-6多不饱和脂肪酸摄入量增加有关。
Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption.
作者信息
Ciesielski Timothy H, Tosto Giuseppe, Durodoye Razaq O, Rajabali Farid, Akinyemi Rufus O, Byrd Goldie S, Bush William S, Kunkle Brian W, Reitz Christiane, Vance Jeffery M, Pericak-Vance Margaret A, Haines Jonathan L, Williams Scott M
机构信息
Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, 10900 Euclid Ave. Cleveland, OH 44106.
Taub Institute for Research on Alzheimer Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, 630 West 168th Street New York, NY 10032.
出版信息
medRxiv. 2024 Aug 8:2024.08.07.24311637. doi: 10.1101/2024.08.07.24311637.
INTRODUCTION
Clinical and genetic studies have implicated lipid dysfunction in Alzheimer Disease (AD) pathogenesis. However, lipid consumption at the individual-level does not vary greatly within most cohorts, and multiple lipids are rarely measured in any one study.
METHODS
Mean country-level lipid intakes were compared to Age-Standardized Alzheimer-Disease-Incidence-Rates(ASAIR) in 183 countries across all inhabited continents. Penalized spline regression and multivariable-adjusted linear regression, including a lag between intake and incidence, were used to assess the relationships between five lipid intakes and ASAIR. Validation was conducted using longitudinal within-country changes between 1990 and 2019.
RESULTS
Omega6 Polyunsaturated-Fatty-Acid(PUFA) intake exhibited a positive linear relationship with ASAIR(multivariable-adjusted model: β=2.44; 95%CI: 1.70, 3.19; p=1.38×10). ASAIR also increased with saturated-fat, trans-fat, and dietary-cholesterol up to a threshold. The association between Omega6-PUFA and ASAIR was confirmed using longitudinal intake changes.
DISCUSSION
Decreasing Omega6-PUFA consumption on the country-level may have substantial benefits in reducing the country-level burden of AD.
引言
临床和遗传学研究表明脂质功能障碍与阿尔茨海默病（AD）的发病机制有关。然而，在大多数队列中，个体层面的脂质摄入量变化不大，并且在任何一项研究中很少对多种脂质进行测量。
方法
将所有有人居住大陆的183个国家的国家层面平均脂质摄入量与年龄标准化阿尔茨海默病发病率（ASAIR）进行比较。使用惩罚样条回归和多变量调整线性回归（包括摄入量和发病率之间的滞后）来评估五种脂质摄入量与ASAIR之间的关系。利用1990年至2019年间国家内部的纵向变化进行验证。
结果
ω-6多不饱和脂肪酸（PUFA）摄入量与ASAIR呈正线性关系（多变量调整模型：β=2.44；95%置信区间：1.70，3.19；p=1.38×10）。饱和脂肪、反式脂肪和膳食胆固醇的摄入量在达到阈值之前，ASAIR也会增加。利用纵向摄入量变化证实了ω-6-PUFA与ASAIR之间的关联。
讨论
在国家层面减少ω-6-PUFA的摄入量可能对减轻国家层面的AD负担有很大益处。
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