J Drugs Dermatol. 2023 Mar 1;22(3):265-270. doi: 10.36849/JDD.7345.
Antibiotic resistance related to prolonged antibiotic use is an emerging threat to public health.
To evaluate recent trends in oral antibiotic use for acne treatment.
A retrospective study was conducted from January 2014 through September 2016 using the IBM MarketScan® claims database. Patients were aged ≥9 years, prescribed an oral antibiotic, and diagnosed with acne vulgaris on 2 separate occasions. The primary outcome was the duration of oral antibiotic treatment over 12 months; continuous use was defined as ≤30-day gap between prescriptions.
The most commonly prescribed antibiotic treatments (N=46,267) were doxycycline (36.7%) and minocycline (36.5%). Overall, 36%, 18%, 10%, and 5% of patients continuously used any oral antibiotic at 3, 6, 9, and 12 months, respectively. Among patients who continuously used tetracyclines, a similar percentage was prescribed minocycline (40.2%, 18.6%, 10.5%, and 5.1%) vs doxycycline (34.7%, 14.6%, 7.7%, and 3.9%) at 3, 6, 9, and 12 months, respectively. A greater percentage of patients continued use of tetracyclineclass antibiotics than other therapeutic classes.
Retrospective analysis of health-care claims data. Relatively short study duration.
Nearly 20% of patients continuously used oral antibiotics for ≥6 months, exceeding American Academy of Dermatology guideline recommendations of 3 to 4 months. J Drugs Dermatol. 2023;22(3):265-270. doi:10.36849/JDD.7345.
与长期使用抗生素相关的抗生素耐药性是对公众健康的新兴威胁。
评估痤疮治疗中口服抗生素的最新使用趋势。
采用回顾性研究，使用 IBM MarketScan® 索赔数据库，于 2014 年 1 月至 2016 年 9 月期间进行。患者年龄≥9 岁，接受口服抗生素治疗，且在 2 次不同就诊时被诊断为寻常痤疮。主要结局是 12 个月内口服抗生素治疗的持续时间；连续使用定义为处方之间间隔≤30 天。
最常开的抗生素治疗（N=46267）是多西环素（36.7%）和米诺环素（36.5%）。总体而言，分别有 36%、18%、10%和 5%的患者在 3、6、9 和 12 个月时连续使用任何口服抗生素。在连续使用四环素类药物的患者中，开米诺环素（40.2%、18.6%、10.5%和 5.1%）和多西环素（34.7%、14.6%、7.7%和 3.9%）的比例相似，分别在 3、6、9 和 12 个月时。与其他治疗类别相比，继续使用四环素类抗生素的患者比例更大。
这是一项健康保险索赔数据的回顾性分析。研究持续时间相对较短。
近 20%的患者连续使用口服抗生素≥6 个月，超过美国皮肤病学会指南推荐的 3 至 4 个月。J 皮肤病学杂志。2023;22(3):265-270. doi:10.36849/JDD.7345.
