Alwasila Roba, Berg Alaina, Colaizy Tarah, Smith Abigail, Evans James, Murad Mohammad Hassan, Bhutta Zulfiqar Ahmed, Imdad Aamer
College of Public Health The University of Iowa Iowa City Iowa USA.
The University of Iowa Carver College of Medicine Iowa City Iowa USA.
JPGN Rep. 2024 Jun 24;5(3):342-346. doi: 10.1002/jpr3.12102. eCollection 2024 Aug.
Human milk has been shown to reduce severe morbidity in preterm/low-birth-weight infants and is therefore the recommended nutritional source. When infants cannot receive maternal milk, donor human milk (DHM) is recommended. The use of human milk banking facilities is increasing to meet the need for DHM. DHM is unique compared to maternal milk as it must be processed and stored. The processing and storage of animal milk has been more rigorously studied than human milk and can serve as proxy to create DHM banking guidelines.
We will search electronic databases, grey literature, and the websites of relevant international organizations. We will include studies that evaluated the impact of storage, handling, and treatment on the nutritional quality and safety of animal milk. We will not restrict study date, language, or design. If sufficient homogeneity exists between studies, we will conduct a meta-analysis. We will evaluate the methodological quality of each study using the SYRCLE's (Systematic Review Centre for Laboratory Animal Experimentation) risk of bias tool. (1) We will evaluate the overall certainty of the evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach.
In this systematic review and meta-analysis, commissioned by the World Health Organization, we will synthesize the available literature regarding the impact of various storage, handling, and treatment practices on the nutritional quality and safety of animal milk.
已证实母乳可降低早产/低出生体重儿的严重发病率，因此是推荐的营养来源。当婴儿无法获得母乳时，建议使用捐赠母乳（DHM）。母乳库设施的使用正在增加，以满足对DHM的需求。与母乳相比，DHM具有独特性，因为它必须经过加工和储存。对动物奶加工和储存的研究比对母乳的研究更为严格，可作为制定DHM库指南的参考。
我们将检索电子数据库、灰色文献以及相关国际组织的网站。我们将纳入评估储存、处理和治疗对动物奶营养质量和安全性影响的研究。我们不会限制研究日期、语言或设计。如果各研究之间存在足够的同质性，我们将进行荟萃分析。我们将使用SYRCLE（实验动物实验系统评价中心）的偏倚风险工具评估每项研究的方法学质量。（1）我们将使用推荐分级评估、制定和评价方法评估证据的总体确定性。
在这项由世界卫生组织委托开展的系统评价和荟萃分析中，我们将综合现有文献，探讨各种储存、处理和治疗方法对动物奶营养质量和安全性的影响。
