Berg Alaina, Rani Uzma, Colaizy Tarah, Smith Abigail, Evans James, Murad Mohammad H, Bhutta Zulfiqar A, Imdad Aamer
The University of Iowa Carver College of Medicine Iowa City Iowa USA.
Stead Family Department of Pediatrics, Division of Neonatology University of Iowa Carver College of Medicine Iowa City Iowa USA.
JPGN Rep. 2024 Jun 24;5(3):347-352. doi: 10.1002/jpr3.12101. eCollection 2024 Aug.
Breast milk is the recommended nutritional source for newborns and has been associated with decreased morbidity in low-birth-weight and preterm infants. In situations where breast milk is not available, donor breast milk is an alternative. Milk banking is becoming increasingly common worldwide to meet this need. Although the benefits of donor breast milk for the recipient infant are well established, the health impact on the breast milk donor and the infant of the breast milk donor is an area of current research. We aim to synthesize and evaluate the available evidence regarding the impact of donating breast milk on the health, lactation, and well-being of the breast milk donor, and the health and growth of the infant of the breast milk donor.
We will search electronic databases, grey literature, and the websites of relevant international organizations. We will include studies that involve lactating women and their infants, healthy or with health conditions, who donate breast milk, without restrictions on study date, language, or study design. If sufficient homogeneity exists between studies, we will complete meta-analyses. We will evaluate the risk of bias using the Risk of Bias tool or the Cochrane Risk of Bias in Non-Randomized Studies tool. We will evaluate the overall certainty of the evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach.
In this systematic review and meta-analysis, we will summarize the current literature regarding the effects of human milk donation on human milk donors and their infants.
母乳是新生儿推荐的营养来源，且与低体重和早产婴儿发病率降低有关。在无法获得母乳的情况下，捐赠母乳是一种替代选择。为满足这一需求，母乳库在全球范围内越来越普遍。尽管捐赠母乳对受赠婴儿的益处已得到充分证实，但捐赠母乳对母乳捐赠者及其婴儿健康的影响是当前的一个研究领域。我们旨在综合并评估现有证据，以了解捐赠母乳对母乳捐赠者的健康、泌乳和幸福感以及母乳捐赠者婴儿的健康和生长的影响。
我们将检索电子数据库、灰色文献以及相关国际组织的网站。我们将纳入涉及捐赠母乳的哺乳期妇女及其婴儿（健康或患有健康问题）的研究，对研究日期、语言或研究设计不设限制。如果研究之间存在足够的同质性，我们将进行荟萃分析。我们将使用偏倚风险工具或Cochrane非随机研究中的偏倚风险工具评估偏倚风险。我们将使用推荐分级评估、制定和评价方法评估证据的总体确定性。
在这项系统评价和荟萃分析中，我们将总结当前关于母乳捐赠对母乳捐赠者及其婴儿影响的文献。
