Xie Chengxin, Ren Yu, He Qiang, Wang Chenglong, Luo Hua
Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Front Cardiovasc Med. 2024 Aug 1;11:1459062. doi: 10.3389/fcvm.2024.1459062. eCollection 2024.
The arteriosclerosis index, defined as the ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol (NHHR), has emerged as a novel biomarker for various diseases. The relationship between NHHR and lumbar bone mineral density (BMD) has not been previously examined.
This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. NHHR was calculated as (total cholesterol-high-density lipoprotein cholesterol)/high-density lipoprotein cholesterol. Lumbar BMD was calculated to scores. Weighted multivariate linear regression, subgroup analysis, interaction analysis, generalized additive model, and two-piecewise linear regression were used.
A total of 8,602 participants were included. The negative association between NHHR and lumbar BMD was consistent and significant (Model 1: = -0.039, 95% CI: -0.055, -0.023, < 0.001; Model 2: = -0.045, 95% CI: -0.062, -0.027, < 0.001; Model 3: = -0.042, 95% CI: -0.061, -0.023, < 0.001). The linear relationship between NHHR and lumbar BMD was significantly influenced by body mass index ( for interaction = 0.012) and hypertension ( for interaction 0.047). Non-linear associations between NHHR and lumbar BMD scores were observed in specific populations, including U-shaped, reverse U-shaped, L-shaped, reverse L-shaped, and U-shaped relationships among menopausal females, underweight participants, those with impaired glucose tolerance, those with diabetes mellitus and those taking anti-hyperlipidemic drugs, respectively.
NHHR exhibited a negative association with lumbar BMD, but varying across specific populations. These findings suggest that NHHR should be tailored to individual levels to mitigate bone loss through a personalized approach. Individuals at heightened risk of cardiovascular disease should focus on their bone health.
动脉硬化指数定义为非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇之比（NHHR），已成为多种疾病的新型生物标志物。此前尚未研究过NHHR与腰椎骨密度（BMD）之间的关系。
这项横断面研究分析了2011 - 2018年美国国家健康与营养检查调查（NHANES）的数据。NHHR计算为（总胆固醇 - 高密度脂蛋白胆固醇）/高密度脂蛋白胆固醇。腰椎骨密度计算为得分。使用加权多元线性回归、亚组分析、交互作用分析、广义相加模型和两段式线性回归。
共纳入8602名参与者。NHHR与腰椎骨密度之间的负相关是一致且显著的（模型1：β = -0.039，95%可信区间：-0.055，-0.023，P < 0.001；模型2：β = -0.045，95%可信区间：-0.062，-0.027，P < 0.001；模型3：β = -0.042，95%可信区间：-
