Ando Tomoko, Kubota Masaomi, Yasukawa Tsutomu, Miyase Taishi, Ishiguro Kiyona, Esaki Yuya, Kato Aki, Kokuzawa Satoko, Hirano Yoshio, Sakaguchi Hirokazu
Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, Gifu, 501-1194, Japan.
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Am J Ophthalmol Case Rep. 2024 Jul 17;36:102126. doi: 10.1016/j.ajoc.2024.102126. eCollection 2024 Dec.
To report a case of a full-thickness macular hole (FTMH) associated with a retinal pigment epithelium (RPE) tear after anti-vascular endothelial growth factor (anti-VEGF) therapy for neovascular age-related macular degeneration (nvAMD), which was successfully closed by vitreous surgery.
A 73-year-old man with nvAMD in the right eye received an intravitreal aflibercept injection due to enlarged pigment epithelial detachment. However, 2 days after the third injection, the patient experienced a sudden decline in vision. An FTMH with a tear in the underlying RPE was detected. The FTMH was closed using vitrectomy combined with the inverted internal limiting membrane (ILM) flap technique.
Our case highlights a rare complication of both an FTMH and an RPE tear after anti-VEGF therapy. Vitrectomy, with the inverted ILM flap technique, proved effective in closing the FTMH despite the complexity of the case.
报告1例在抗血管内皮生长因子（抗VEGF）治疗新生血管性年龄相关性黄斑变性（nvAMD）后出现的与视网膜色素上皮（RPE）撕裂相关的全层黄斑裂孔（FTMH）病例，该病例通过玻璃体手术成功封闭。
一名右眼患有nvAMD的73岁男性因色素上皮脱离扩大接受了玻璃体内阿柏西普注射。然而，在第三次注射后2天，患者视力突然下降。检测到一个伴有下方RPE撕裂的FTMH。使用玻璃体切除术联合倒置内界膜（ILM）瓣技术封闭了FTMH。
我们的病例突出了抗VEGF治疗后FTMH和RPE撕裂这一罕见并发症。尽管病例复杂，但采用倒置ILM瓣技术的玻璃体切除术被证明对封闭FTMH有效。
