Isomura S, Suzuki S, Sato Y
Dev Biol Stand. 1985;61:531-7.
A major increase in the number of pertussis cases was observed subsequent to the complete discontinuation of mass-immunization against the disease in Aichi Prefecture in central Japan. The discontinuation of DTP vaccine started in 1975 and lasted for five years. Since 1978, epidemics of pertussis were observed in children mainly in the unvaccinated age groups. The outbreaks continued in the following year and subsided in 1980 when vaccination was reintroduced. Since 1981 newly developed acellular pertussis vaccines have been used for mass-immunization. The incidence of pertussis has remained low and no epidemics of the disease have been observed among children vaccinated with the new vaccines. During the epidemics in Aichi Prefecture, the protective efficacy of the new vaccines were studied in 21 vaccinees with intrafamiliar exposure to the disease. Clinical observations showed that the vaccine reduced the attack rate of pertussis after household contacts from 85% to 9.5%. It was concluded that the vaccine effectively prevented pertussis.
在日本中部爱知县完全停止针对百日咳的大规模免疫接种后，观察到百日咳病例数大幅增加。白喉、破伤风、百日咳（DTP）疫苗的接种停止于1975年，并持续了五年。自1978年以来，百日咳疫情主要在未接种疫苗的年龄组儿童中出现。疫情在次年持续，并在1980年重新引入疫苗接种时平息。自1981年以来，新研发的无细胞百日咳疫苗已用于大规模免疫接种。百日咳发病率一直较低，在接种新疫苗的儿童中未观察到该疾病的疫情。在爱知县疫情期间，对21名在家庭中接触过该疾病的疫苗接种者研究了新疫苗的保护效力。临床观察表明，该疫苗将家庭接触后百日咳的发病率从85%降低到了9.5%。得出的结论是，该疫苗有效预防了百日咳。
