Mayo Clinic, Phoenix, Arizona, USA.
Washington University School of Medicine, St. Louis, Missouri, USA.
Headache. 2024 Sep;64(8):912-930. doi: 10.1111/head.14797. Epub 2024 Aug 16.
To identify and disseminate research priorities for the headache field that should be areas of research focus during the next 10 years.
Establishing research priorities helps focus and synergize the work of headache investigators, allowing them to reach the most important research goals more efficiently and completely.
The Headache Research Priorities organizing and executive committees and working group chairs led a multistakeholder and international group of experts to develop headache research priorities. The research priorities were developed and reviewed by clinicians, scientists, people with headache, representatives from headache organizations, health-care industry representatives, and the public. Priorities were revised and finalized after receiving feedback from members of the research priorities working groups and after a public comment period.
Twenty-five research priorities across eight categories were identified: human models, animal models, pathophysiology, diagnosis and management, treatment, inequities and disparities, research workforce development, and quality of life. The priorities address research models and methods, development and optimization of outcome measures and endpoints, pain and non-pain symptoms of primary and secondary headaches, investigations into mechanisms underlying headache attacks and chronification of headache disorders, treatment optimization, research workforce recruitment, development, expansion, and support, and inequities and disparities in the headache field. The priorities are focused enough that they help to guide headache research and broad enough that they are widely applicable to multiple headache types and various research methods.
These research priorities serve as guidance for headache investigators when planning their research studies and as benchmarks by which the headache field can measure its progress over time. These priorities will need updating as research goals are met and new priorities arise.
确定并传播头痛领域的研究重点，这些重点应成为未来 10 年的研究重点领域。
确定研究重点有助于集中和协同头痛研究人员的工作，使他们能够更高效、更全面地实现最重要的研究目标。
头痛研究重点组织和执行委员会以及工作组主席领导了一个多利益相关者和国际专家组，制定了头痛研究重点。这些研究重点由临床医生、科学家、头痛患者、头痛组织代表、医疗保健行业代表和公众组成的专家小组制定和审查。在收到研究重点工作组成员的反馈意见并经过公开意见征询期后，对重点进行了修订和最终确定。
确定了涵盖八个类别的 25 项研究重点：人类模型、动物模型、病理生理学、诊断和管理、治疗、公平性和差距、研究人员队伍发展以及生活质量。这些重点涉及研究模型和方法、开发和优化结局测量和终点、原发性和继发性头痛的疼痛和非疼痛症状、头痛发作和头痛障碍慢性化机制的研究、治疗优化、研究人员队伍的招募、发展、扩展和支持以及头痛领域的公平性和差距。这些重点足够集中，有助于指导头痛研究；范围足够广泛，可广泛适用于多种头痛类型和各种研究方法。
这些研究重点为头痛研究人员规划研究提供了指导，并为头痛领域衡量随着时间的推移取得的进展提供了基准。随着研究目标的实现和新重点的出现，这些重点将需要更新。
