Department of Internal Medicine, 1500 East Medical Center Dr Ann Arbor, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Institute for Healthcare Policy and Innovation, University of Michigan, 2800 Plymouth Rd, Ann Arbor, Michigan, USA.
Alzheimers Dement. 2024 Oct;20(10):6755-6764. doi: 10.1002/alz.14092. Epub 2024 Aug 16.
Geographic variation in diagnosed cases of Alzheimer's disease and related dementias (ADRD) could be due to underlying population risk or differences in intensity of new case identification. Areas with low ADRD diagnostic intensity could be targeted for additional surveillance efforts.
Medicare claims were used for a cohort of older adults across hospital referral regions (HRRs). ADRD-specific regional diagnosis intensity was measured as the ratio of expected new ADRD cases (estimated using population demographics, risk factors, and practice intensity) compared to observed ADRD-diagnosed cases.
Crude new ADRD diagnosis rate ranged from 1.7 to 5.4 per 100 across HRRs. ADRD-specific diagnosis intensity ranged from 0.69 to 1.47 and varied most for Black, Hispanic, and the youngest (66-74) subgroups. Across all subgroups, ADRD diagnosis intensity was associated with 2-fold difference in receiving an ADRD diagnosis.
Where one resides influences the likelihood of receiving an ADRD diagnosis, particularly among those 66-74 years of age and minoritized groups.
Rate of new Alzheimer's disease and related dementias (ADRD) case identification varies geographically across the United States. Variation in case identification is greatest in Black, Hispanic, and young-old groups. Intensity of diagnosis (ie, case identification) unrelated to population risk differs across place. Likelihood of receiving an ADRD diagnosis varies 2-fold based on place of residence.
阿尔茨海默病和相关痴呆症(ADRD)的诊断病例在地理上的差异可能是由于潜在的人群风险或新病例识别强度的差异所致。诊断强度较低的 ADRD 地区可能是额外监测的目标。
使用医疗保险索赔数据对医院转诊区域(HRR)内的老年人群进行了队列研究。ADRD 特定区域诊断强度的测量方法是将预期的新 ADRD 病例数(使用人口统计学、风险因素和实践强度估计)与观察到的 ADRD 诊断病例数进行比较。
HRR 之间的新 ADRD 诊断率从每 100 人 1.7 例到 5.4 例不等。ADRD 特定诊断强度从 0.69 到 1.47 不等,在黑人和西班牙裔以及最年轻(66-74 岁)亚组中变化最大。在所有亚组中,ADRD 诊断强度与接受 ADRD 诊断的可能性差异呈 2 倍关系。
居住地点会影响接受 ADRD 诊断的可能性,尤其是在 66-74 岁和少数族裔群体中。
美国各地新的阿尔茨海默病和相关痴呆症(ADRD)病例识别率在地理上存在差异。在黑人和西班牙裔以及年轻老年人中,病例识别的差异最大。诊断强度(即病例识别)与人群风险无关,其在不同地区存在差异。基于居住地的不同,接受 ADRD 诊断的可能性差异可达 2 倍。