Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Alzheimers Dement. 2021 Dec;17(12):1966-1975. doi: 10.1002/alz.12362. Epub 2021 May 27.
The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.
We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores.
The 2020 US Census-adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7-11.9): 10.0% among non-Hispanic Whites, 14.0% among Hispanics, and 18.6% among non-Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75-6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98-14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men.
The number of people with clinical AD will increase as the "baby boom" generation reaches older ages, exerting a strong upward influence on disease burden.
临床阿尔茨海默病（AD）和轻度认知障碍患者的估计数有助于了解疾病负担。
我们使用 10342 名认知测试得分参与者的拟二项式回归模型来估计认知障碍患者。
2020 年美国人口普查调整后的临床 AD 患病率为 11.3%（95%置信区间[CI] = 10.7-11.9）：非西班牙裔白种人占 10.0%，西班牙裔占 14.0%，非西班牙裔黑人占 18.6%。我们估计，2020 年有 607 万人（95%CI = 5.75-6.38）患有临床 AD，到 2060 年将增加到 1385 万人（95%CI = 12.98-14.74），其中西班牙裔增加 423%，黑人增加 192%，白人增加 63%。然而，与男性相比，85 岁以上人群和女性的发病率在后期预计会有更大的增长。
随着“婴儿潮”一代年龄的增长，临床 AD 患者的数量将会增加，这将对疾病负担产生强烈的上行影响。
