一种用于药物性肝损伤中过氧化氢检测的新型近红外二区荧光探针。
A novel NIR-II fluorescent probe for hydrogen peroxide detection in drug-induced liver injury.
机构信息
State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), School of Materials Science and Engineering, Nanjing, Jiangsu, China.
出版信息
Chem Commun (Camb). 2024 Aug 29;60(71):9618-9621. doi: 10.1039/d4cc03512g.
The synthesis of HO-activatable small molecules in the second near-infrared (NIR-II) window remains challenging. We present the NIR-II probe Z-1065 for real-time detection of HO. Z-1065 demonstrates high sensitivity and selectivity towards HO and effectively monitors HO generation in drug-induced liver injury (DILI) mouse models.
HO 激活型小分子在第二近红外（NIR-II）窗口中的合成仍然具有挑战性。我们提出了 NIR-II 探针 Z-1065 用于实时检测 HO。Z-1065 对 HO 具有高灵敏度和选择性，并能有效监测药物性肝损伤（DILI）小鼠模型中 HO 的产生。
Zotero 插件