一种用于检测抗结核药物诱导的肝损伤的turn-on 探针：近红外二区荧光/光声成像。
A turn-on probe for detecting antituberculotic drug-induced liver injury in mice NIR-II fluorescence/optoacoustic imaging.
机构信息
State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.
出版信息
Chem Commun (Camb). 2021 Aug 5;57(63):7842-7845. doi: 10.1039/d1cc02845f.
PMID:34278391
Abstract
A turn-on optoacoustic and NIR-II fluorescent probe for imaging antituberculotic drug-induced liver injury has been developed. Probe TC-H2O2 responds to hepatic H2O2, thus releasing chromophore TC-NN, which displays prominent NIR-II fluorescence and optoacoustic signals for diagnosing liver injury.
摘要
一种用于成像抗结核药物诱导的肝损伤的转光光电声和近红外二区荧光探针已经被开发出来。探针 TC-H2O2 响应肝内的 H2O2，从而释放出生色团 TC-NN，其显示出显著的近红外二区荧光和光电声信号，用于诊断肝损伤。
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