通往高价值吲哚官能化乙烯基磺酰氟和烯丙基磺酰氟的门户。
A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides.
作者信息
Huang Wenzhuo, Fayad Eman, Abu Ali Ola A, Qin Hua-Li
机构信息
State Key Laboratory of Silicate Materials for Architectures; and School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
出版信息
Org Biomol Chem. 2024 Sep 11;22(35):7117-7120. doi: 10.1039/d4ob01213e.
A practical and efficient method for the C-3 site selective alkenylation of indoles was developed for constructing novel indole-functionalized vinyl sulfonyl fluorides and indolyl allylic sulfonyl fluorides. The reaction is accomplished with exclusive regio- and stereoselectivity without using transition metal catalysts, providing novel products of great potential value in medicinal chemistry, chemical biology, and drug discovery.
开发了一种实用且高效的方法用于吲哚的C-3位选择性烯基化反应，以构建新型的吲哚官能化乙烯基磺酰氟和吲哚基烯丙基磺酰氟。该反应在不使用过渡金属催化剂的情况下，以独特的区域和立体选择性完成，提供了在药物化学、化学生物学和药物发现中具有巨大潜在价值的新型产物。
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