Zhang Xu, Fang Wan-Yin, Qin Hua-Li
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
Org Lett. 2022 Jun 10;24(22):4046-4051. doi: 10.1021/acs.orglett.2c01509. Epub 2022 May 27.
A convenient protocol for the exclusively regio- and stereoselective installation of a bromine atom on the 2-arylvinylsulfonyl fluorides using lithium bromide (LiBr) as the bromine source was described, providing ()-1-bromo-2-arylethene-1-sulfonyl fluorides (-BASF) with versatile reactive handles (bromide, vinyl, and sulfonyl fluoride) in ≤88% yield. Meanwhile, -BASF molecules displayed various reactivities in a series of chemical transformations.
描述了一种便捷的方法，以溴化锂（LiBr）作为溴源，将溴原子区域和立体选择性地专一安装在2-芳基乙烯基磺酰氟上，以≤88%的产率提供具有多种反应性官能团（溴、乙烯基和磺酰氟）的（）-1-溴-2-芳基乙烯-1-磺酰氟（-BASF）。同时，-BASF分子在一系列化学转化中表现出各种反应活性。
