Mitchell Stephen, Waring Rosemary
Faculty of Medicine, Imperial College London, London, UK.
School of Biosciences, University of Birmingham, Birmingham, UK.
J Med Biogr. 2025 May;33(2):116-122. doi: 10.1177/09677720241273694. Epub 2024 Aug 16.
Although there had been many previous inklings, the field of xenobiotic metabolism (as we know it today) began with an experiment reported in the 1841 literature proclaiming that the ingestion of benzoic acid led to the subsequent excretion of hippuric acid in human urine. A metabolic transformation undertaken by a living organism. One worker involved in the early stages of this discovery was Wilhelm Keller, although very little information about him is readily available. Hopefully, this article will go some way to counter this dearth and also highlight Keller's pioneering contribution in the development of the fields of drug metabolism and xenobiochemistry.
尽管此前已有许多相关线索，但（我们如今所熟知的）异源物代谢领域始于1841年文献中报道的一项实验，该实验宣称摄入苯甲酸会导致人体尿液中随后排出马尿酸。这是一种由生物体进行的代谢转化。参与这一发现早期阶段的一位研究者是威廉·凯勒，不过关于他的信息很难轻易获取。希望本文能在一定程度上弥补这一不足，同时突出凯勒在药物代谢和异源生物化学领域发展中的开创性贡献。
