Division of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD.
J Pediatr. 2024 Dec;275:114241. doi: 10.1016/j.jpeds.2024.114241. Epub 2024 Aug 14.
To determine the association between indoor air pollution and respiratory morbidities in children with bronchopulmonary dysplasia (BPD) recruited from the multicenter BPD Collaborative.
A cross-sectional study was performed among participants <3 years old in the BPD Collaborative Outpatient Registry. Indoor air pollution was defined as any reported exposure to tobacco or marijuana smoke, electronic cigarette emissions, gas stoves, and/or wood stoves. Clinical data included acute care use and chronic respiratory symptoms in the past 4 weeks.
A total of 1011 participants born at a mean gestational age of 26.4 ± 2.2 weeks were included. Most (66.6%) had severe BPD. More than 40% of participants were exposed to ≥1 source of indoor air pollution. The odds of reporting an emergency department visit (OR, 1.7; 95% CI, 1.18-2.45), antibiotic use (OR, 1.9; 95% CI, 1.12-3.21), or a systemic steroid course (OR, 2.18; 95% CI, 1.24-3.84) were significantly higher in participants reporting exposure to secondhand smoke (SHS) compared with those without SHS exposure. Participants reporting exposure to air pollution (not including SHS) also had a significantly greater odds (OR, 1.48; 95% CI, 1.08-2.03) of antibiotic use as well. Indoor air pollution exposure (including SHS) was not associated with chronic respiratory symptoms or rescue medication use.
Exposure to indoor air pollution, especially SHS, was associated with acute respiratory morbidities, including emergency department visits, antibiotics for respiratory illnesses, and systemic steroid use.
确定多中心支气管肺发育不良（BPD）协作研究中招募的患有 BPD 的儿童的室内空气污染与呼吸道疾病的相关性。
在 BPD 协作门诊登记处，对<3 岁的参与者进行了横断面研究。室内空气污染定义为任何报告的接触烟草或大麻烟雾、电子烟排放物、煤气炉和/或柴火炉。临床数据包括过去 4 周内的急性护理使用情况和慢性呼吸道症状。
共纳入 1011 名平均胎龄为 26.4±2.2 周出生的参与者。大多数（66.6%）患有严重 BPD。超过 40%的参与者暴露于≥1 种室内空气污染源。与未暴露于 SHS 的参与者相比，报告急诊就诊（OR，1.7；95%CI，1.18-2.45）、抗生素使用（OR，1.9；95%CI，1.12-3.21）或全身类固醇疗程（OR，2.18；95%CI，1.24-3.84）的参与者报告接触二手烟（SHS）的可能性显著更高。报告接触空气污染（不包括 SHS）的参与者也有更高的抗生素使用（OR，1.48；95%CI，1.08-2.03）的可能性。室内空气污染暴露（包括 SHS）与慢性呼吸道症状或抢救药物使用无关。
暴露于室内空气污染，尤其是 SHS，与急性呼吸道疾病相关，包括急诊就诊、呼吸道疾病的抗生素治疗和全身类固醇使用。
