前列腺导管腺癌 13 年后在前尿道复发：病例报告。
Prostate ductal adenocarcinoma exhibiting a late recurrence in the anterior urethra 13 years post-total prostatectomy: a case report.
机构信息
Department of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.
Department of Pathology, Yokohama City University Medical Center, Yokohama, Japan.
出版信息
J Med Case Rep. 2024 Aug 17;18(1):371. doi: 10.1186/s13256-024-04699-6.
BACKGROUND
Prostate ductal adenocarcinoma, a rare histology observed in 0.4-0.8% of all prostate cancers, is treated similarly to acinar adenocarcinoma but tends to have a higher likelihood of metastasis, recurrence, and poorer prognosis.
CASE PRESENTATION
A 73-year-old Asian-Japanese male presented with gross hematuria, with investigations revealing a prostate ductal adenocarcinoma. Subsequent radical prostatectomy indicated a Gleason score of 8 with no lymph node metastasis. Despite initial prostate-specific antigen level reductions post-prostatectomy and salvage radiation therapy due to recurring elevated prostate-specific antigen levels, no recurrence was evident until 13 years later. A tumor in the anterior urethra was identified as metastasis of his prostate ductal adenocarcinoma.
CONCLUSION
This report presents an uncommon case of prostate ductal adenocarcinoma exhibiting a late recurrence in the anterior urethra 13 years post-radical prostatectomy.
背景
前列腺导管腺癌是一种罕见的组织学类型，仅占所有前列腺癌的 0.4%-0.8%，其治疗方法与腺泡腺癌相似，但转移、复发和预后较差的可能性更高。
病例介绍
一名 73 岁的亚裔日本男性因肉眼血尿就诊，检查发现前列腺导管腺癌。随后行根治性前列腺切除术，病理显示 Gleason 评分为 8 分，无淋巴结转移。尽管前列腺特异性抗原水平在前列腺切除术后和挽救性放疗后有所下降，但由于前列腺特异性抗原水平再次升高，仍出现复发，直到 13 年后才发现复发。尿道前部的肿瘤被诊断为前列腺导管腺癌的转移。
结论
本报告介绍了一例罕见的前列腺导管腺癌病例，该患者在根治性前列腺切除术后 13 年尿道前部出现晚期复发。
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