Fujiwara Shinnosuke, Ishida Masaru, Arai Eri, Baba Yuto, Anno Tadatsugu, Kobayashi Hiroaki, Miyazaki Yasumasa
Department of Urology Saiseikai Yokohamashi Tobu Hospital Kanagawa Japan.
Department of Pathology Keio University School of Medicine Tokyo Japan.
IJU Case Rep. 2021 Nov 2;5(1):58-61. doi: 10.1002/iju5.12394. eCollection 2022 Jan.
Primary or metastatic urethral tumors are extremely rare. However, treatment strategies differ between primary and metastatic tumors. Therefore, establishing an accurate diagnosis is critically needed for initiating timely and appropriate therapy.
We describe the case of a 79-year-old man with prostate cancer treated with radiotherapy and androgen deprivation therapy. He presented with macroscopic hematuria as a symptom of anterior urethral tumor at follow-up. Endoscopic tumor resection was performed. Hematoxylin and eosin staining showed adenocarcinoma component. Immunohistochemical staining revealed presence of metastatic prostate cancer to the urethra.
Regarding urethral tumors diagnosis, urologists should consider the possibility of metastasis from prostate cancer and perform immunohistochemical examination for establishing accurate diagnosis. Furthermore, if androgen deprivation therapy fails to suppress symptoms, radiotherapy or urethrectomy might be considered.
原发性或转移性尿道肿瘤极为罕见。然而，原发性肿瘤和转移性肿瘤的治疗策略有所不同。因此，为了及时开展恰当的治疗，准确诊断至关重要。
我们描述了一名79岁前列腺癌男性患者的病例，该患者接受了放疗和雄激素剥夺治疗。随访时，他出现肉眼血尿，这是前尿道肿瘤的症状。进行了内镜下肿瘤切除术。苏木精-伊红染色显示腺癌成分。免疫组化染色显示前列腺癌转移至尿道。
对于尿道肿瘤的诊断，泌尿外科医生应考虑前列腺癌转移的可能性，并进行免疫组化检查以确立准确诊断。此外，如果雄激素剥夺治疗未能抑制症状，可考虑放疗或尿道切除术。
