Dutta Indranil, Gholap Sandeep Suryabhan, Rahman Mohammad Misbahur, Tan Davin, Zhang Lili, Dighe Shashikant U, Huang Kuo-Wei
Chemistry Program, Division of Physical Sciences and Engineering and KAUST Catalysis Center, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.
Agency for Science, Technology and Research (A*STAR), Institute of Sustainability for Chemicals, Energy and Environment (ICSE2), Singapore, 138634, Singapore.
Chem Asian J. 2024 Nov 18;19(22):e202400497. doi: 10.1002/asia.202400497. Epub 2024 Oct 22.
The growing emphasis on sustainable chemistry has driven research into utilizing carbon dioxide (CO) as a nontoxic, abundant, and cost-effective C1 building block. CO offers a promising avenue for direct conversion into valuable chemicals ranging from fuels to pharmaceuticals. This review focuses on the utilization of CO for reductive N-formylation/N-methylation reactions of various amines, providing advantages over conventional methods involving toxic CO and other methylating reagents. The approach employs readily available reductants such as silane, borane reagents, and hydrogen (H) The discussion encompasses recent developments in transition metal and organocatalyst systems for these reactions, highlighting mechanistic interpretations and factors influencing product selectivity.
对可持续化学日益增长的重视推动了利用二氧化碳（CO）作为无毒、丰富且具有成本效益的C1结构单元的研究。CO为直接转化为从燃料到药物等各种有价值的化学品提供了一条有前景的途径。本综述聚焦于利用CO进行各种胺的还原N-甲酰化/N-甲基化反应，相较于涉及有毒CO和其他甲基化试剂的传统方法具有优势。该方法采用易于获得的还原剂，如硅烷、硼烷试剂和氢气（H）。讨论涵盖了用于这些反应的过渡金属和有机催化剂体系的最新进展，突出了机理阐释以及影响产物选择性的因素。
