Study on the antibacterial activity of ceftazidime in an in vitro pharmacokinetic model.

A kinetic model was used to evaluate the activity of ceftazidime against recently isolated bacterial strains. The microorganisms were subjected in vitro to drug concentrations simulating the serum kinetics of ceftazidime after i.v. administration of 1 g of the drug. In these conditions ceftazidime showed a bactericidal effect lasting up to 12 h, even at concentrations below the MICs for some strains. In no case did resistant populations develop after exposure to the drug.