Deforges L, Le Van Thoi J, Soussy C J, Duval J, Thabaut A, Meyran M, Acar J F, Kitzis M D, Fleurette J, Coulet M
Pathol Biol (Paris). 1983 May;31(5):375-8.
This work reports a multicenter study of antibacterial activity of ceftazidime, a new third generation cephalosporin, on hospital Gram negative rods. Enterobacteriaceae are very sensitive to ceftazidime with a maximum number of strains inhibited by 1 microgram/ml or less (modal MIC 0, 125 microgram/ml); some resistant strains are observed, particularly among Enterobacter and Citrobacter. Activity of ceftazidime on Pseudomonas aeruginosa is superior to other third generation cephalosporins; modal MIC is 1 microgram/ml and 88% of the strains are inhibited by 4 microgram/ml or less. Acinetobacter are less sensitive to ceftazidime, with a modal MIC of 8 microgram/ml.
本研究报告了一项关于新型第三代头孢菌素头孢他啶对医院革兰氏阴性杆菌抗菌活性的多中心研究。肠杆菌科对头孢他啶非常敏感，大多数菌株在1微克/毫升或更低浓度时受到抑制（最低抑菌浓度模式值为0.125微克/毫升）；观察到一些耐药菌株，尤其是在肠杆菌属和柠檬酸杆菌属中。头孢他啶对铜绿假单胞菌的活性优于其他第三代头孢菌素；最低抑菌浓度模式值为1微克/毫升，88%的菌株在4微克/毫升或更低浓度时受到抑制。不动杆菌对头孢他啶不太敏感，最低抑菌浓度模式值为8微克/毫升。
