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银屑病患者发生银屑病关节炎的风险因素:误区、陷阱和要点。

Risk factors for psoriatic arthritis development in psoriasis patients: myths, pitfalls, and pearls.

机构信息

Department of Internal Medicine B & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, and School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.

Department of Internal Medicine B & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, and School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel; and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK.

出版信息

Clin Exp Rheumatol. 2024 Sep;42(9):1856-1866. doi: 10.55563/clinexprheumatol/h6176m. Epub 2024 Aug 8.

Abstract

Psoriatic arthritis (PsA) predominantly emerges in individuals previously diagnosed with psoriasis (PsO), offering a unique opportunity to study the transition from PsO to PsA. This progression provides a window to identify characteristics of PsO patients who may develop PsA, facilitating early intervention and potentially informing prevention and treatment strategies. This review evaluates a wide array of research focusing on various risk factors for PsA development. These factors span demographic characteristics, concomitant diseases and habits, characteristics of skin and nail psoriatic disease, and symptoms and imaging abnormalities associated with PsA. By summarising the existing literature, this review critically examines each risk factor, highlighting the strengths and limitations inherent in the studies. Each section of the review not only summarises the current state of knowledge but also includes an expert opinion, culminating in a final concluding remark. This integration allows physicians to utilise the confluence of established literature and ongoing clinical experience, facilitating a rationalised decision-making process that is deeply informed by both empirical evidence and practical insights.

摘要

银屑病关节炎(PsA)主要出现在先前被诊断患有银屑病(PsO)的个体中,为研究从 PsO 到 PsA 的转变提供了独特的机会。这种进展为识别可能发展为 PsA 的 PsO 患者的特征提供了机会,有助于早期干预,并可能为预防和治疗策略提供信息。本综述评估了广泛关注各种 PsA 发展风险因素的研究。这些因素包括人口统计学特征、合并疾病和习惯、皮肤和指甲银屑病特征以及与 PsA 相关的症状和影像学异常。通过总结现有文献,本综述批判性地检查了每个风险因素,强调了研究中固有的优势和局限性。本综述的每个部分不仅总结了当前的知识状况,还包括专家意见,最终得出一个结论性的评价。这种整合使医生能够利用既定文献和正在进行的临床经验的融合,通过经验证据和实际见解的深入结合,促进合理化的决策过程。

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