Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, King Khalid International Airport, Airport Road, 11564, Riyadh, Saudi Arabia.
Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia.
Int J Clin Pharm. 2024 Dec;46(6):1410-1418. doi: 10.1007/s11096-024-01782-2. Epub 2024 Aug 17.
Clozapine has shown great efficacy in treating treatment-resistant schizophrenia, but it is associated with a variety of medication- related safety problems. Despite this, there remains a lack of research on medication errors (MEs) associated with its use.
To characterize the nature and contributory factors of clozapine-related MEs reported from government hospitals and primary care centres in Saudi Arabia (SA).
A cross-sectional analysis was carried out on MEs related to clozapine use reported to the General Administration of Pharmaceutical Care at the Ministry of Health (MOH) in Saudi Arabia between 2018 and 2022. The data were analysed descriptively to examine the nature and contributory factors of MEs.
A total of 1,165 MEs were reported. The majority of reported errors involved patients aged > 18 years old, with 72.2% (n = 841) being male. The central region was found to report errors more frequently (32.3%, n = 376). Pharmacists were reported to detect errors most frequently (59.6%, n = 695). MEs most often occurred in the prescribing stage (77.8%, n = 906), with "missing prescription information" (30.1%, n = 351) being the most frequent finding. The most frequent contributing factor was the lack of policy (33.1%, n = 351). The majority of errors did not reach the patients (92.3%, n = 1,075), and those that did reach patients rarely resulted in harm (0.3%, n = 2).
This study identified areas for improvement which could expedite the development of remedial interventions to reduce the risk of errors.
氯氮平在治疗难治性精神分裂症方面显示出了巨大的疗效，但它与各种药物相关的安全问题有关。尽管如此，关于其使用相关的用药错误（MEs）的研究仍然缺乏。
描述沙特阿拉伯（SA）政府医院和初级保健中心报告的与氯氮平相关的 MEs 的性质和促成因素。
对 2018 年至 2022 年期间向沙特卫生部药学护理总局报告的与氯氮平使用相关的 MEs 进行了横断面分析。对数据进行了描述性分析，以检查 MEs 的性质和促成因素。
共报告了 1165 例 MEs。报告的大多数错误涉及年龄大于 18 岁的患者，其中 72.2%（n=841）为男性。中央地区报告的错误更为频繁（32.3%，n=376）。药剂师报告发现错误的频率最高（59.6%，n=695）。MEs 最常发生在处方阶段（77.8%，n=906），最常见的发现是“处方信息缺失”（30.1%，n=351）。最常见的促成因素是缺乏政策（33.1%，n=351）。大多数错误没有到达患者（92.3%，n=1075），到达患者的错误很少导致伤害（0.3%，n=2）。
本研究确定了需要改进的领域，这可以加快补救干预措施的开发，以降低错误风险。
