Key Laboratory for Anisotropy and Texture of Materials (MoE), School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China.
Department of Prosthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, Shenyang 110001, China.
ACS Appl Mater Interfaces. 2024 Aug 28;16(34):44590-44604. doi: 10.1021/acsami.4c10432. Epub 2024 Aug 17.
Titanium and titanium alloys have the advantages of a low density and a close elastic modulus to natural bone, which can reduce the stress-shielding effect and become one of the first choices for human hard tissue replacement and repair. However, implant site infection is still one of the main reasons for implantation failure. In this paper, 2.5 wt % Ag element was added to Ti-15Mo to obtain a low modulus, and a surface anodization was applied to improve the surface biocompatibility. The elastic modulus, micromorphology, surface elemental valence, corrosion resistance, antimicrobial properties, and cytocompatibility were investigated by mechanical tests, scanning electron microscopy, X-ray photoelectron spectroscopy, electrochemical tests, inductively coupled plasma spectroscopy, plate counting method, and cellular tests. The experimental results showed that the anodized Ti-15Mo-2.5Ag sample exhibited an elastic modulus of 79 GPa, a strong corrosion resistance, a strong antimicrobial ability of ≥99.99%, and good biocompatibility. It was demonstrated that the formation of AgO on the surface and Ag ion release improved the antimicrobial properties and that the structural synergism of silver ions with micro- and nanostructures played an important role in promoting the early spreading of cells and improving the cytocompatibility.
钛及钛合金具有密度低、弹性模量与天然骨接近的优点，可减少应力遮挡效应，成为人体硬组织置换和修复的首选材料之一。但种植体周围感染仍是导致植入失败的主要原因之一。本研究通过在 Ti-15Mo 中添加 2.5wt%Ag 元素，获得低模量，同时进行表面阳极氧化处理以提高表面生物相容性。通过力学性能测试、扫描电子显微镜、X 射线光电子能谱、电化学测试、电感耦合等离子体光谱仪、平板计数法和细胞实验，研究了弹性模量、微观形貌、表面元素价态、耐腐蚀性、抗菌性能和细胞相容性。实验结果表明，阳极氧化处理后的 Ti-15Mo-2.5Ag 样品弹性模量为 79GPa，具有较强的耐腐蚀性和≥99.99%的强抗菌能力，以及良好的生物相容性。研究表明，表面形成的 AgO 和 Ag 离子释放提高了抗菌性能，银离子与微纳结构的协同作用对促进细胞早期铺展和提高细胞相容性起着重要作用。
