Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
J Cell Mol Med. 2024 Aug;28(16):e70003. doi: 10.1111/jcmm.70003.
Pulmonary hypertension (PH) is a chronic progressive vascular disease characterized by abnormal pulmonary vascular resistance and pulmonary artery pressure. The major structural alteration during PH is pulmonary vascular remodelling, which is mainly caused by the imbalance between proliferation and apoptosis of pulmonary vascular cells. Previously, it was thought that apoptosis was the only type of programmed cell death (PCD). Soon afterward, other types of PCD have been identified, including autophagy, pyroptosis, ferroptosis and necroptosis. In this review, we summarize the role of the above five forms of PCD in mediating pulmonary vascular remodelling, and discuss their guiding significance for PH treatment. The current review could provide a better understanding of the correlation between PCD and pulmonary vascular remodelling, contributing to identify new PCD-associated drug targets for PH.
肺动脉高压（PH）是一种以肺血管阻力和肺动脉压异常为特征的慢性进行性血管疾病。PH 过程中的主要结构改变是肺血管重构，这主要是由肺血管细胞的增殖和凋亡失衡引起的。以前，人们认为细胞凋亡是唯一类型的程序性细胞死亡（PCD）。不久之后，其他类型的 PCD 也被鉴定出来，包括自噬、细胞焦亡、铁死亡和坏死性凋亡。在这篇综述中，我们总结了上述五种 PCD 形式在介导肺血管重构中的作用，并讨论了它们对 PH 治疗的指导意义。目前的综述可以更好地理解 PCD 与肺血管重构之间的相关性，有助于确定 PH 相关的新的 PCD 药物靶点。
