ChristianaCare Hospital, 4755 Ogletown-Stanton Road, Newark, DE 19718, United States.
Philadelphia College of Osteopathic Medicine, United States.
Clin Imaging. 2024 Oct;114:110251. doi: 10.1016/j.clinimag.2024.110251. Epub 2024 Aug 14.
The hot cross bun sign is a radiological sign seen on MRI due to pontocerebellar demyelination and loss of neurons along with preservation of the pontine tegmentum and corticospinal tracts which is classically seen in Multiple System Atrophy (MSA). Hot cross buns have been in existence since as early as the 14th century up until the point when Schrag et al. (1998) coupled the appearance of this age-old bread with the T2 imaging characteristics of MSA. Over time the radiological sign has expanded with a differential diagnosis of spinocerebellar ataxia, progressive multifocal leukoencephalopathy, paraneoplastic cerebellar degeneration, and variant Creutzfeldt-Jakob disease.
热十字面包征是一种磁共振成像（MRI）上的影像学征象，由于桥脑小脑脱髓鞘和神经元丢失，同时桥脑被盖和皮质脊髓束得以保留，这在多系统萎缩（MSA）中经典可见。热十字面包自 14 世纪以来就已经存在，直到 Schrag 等人（1998 年）将这种古老面包的外观与 MSA 的 T2 成像特征联系起来。随着时间的推移，该影像学征象的鉴别诊断范围不断扩大，包括脊髓小脑共济失调、进行性多灶性白质脑病、副肿瘤性小脑变性和变异型克雅氏病。
