Pharmacotherapeutic Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Faculty of Pharmacy, Mahsa University, Bandar Saujana Putra, Jenjarom, Selangor, Malaysia.
Life Sci. 2024 Oct 15;355:122991. doi: 10.1016/j.lfs.2024.122991. Epub 2024 Aug 15.
Psoriasis is a chronic inflammatory condition affecting approximately 2 % to 3 % of the global population. The pathogenesis of psoriasis is complex, involving immune dysregulation, hyperproliferation and angiogenesis. It is a multifactorial disease which is influenced by genetic and environmental factors. The development of various therapeutic agents, such as JAK inhibitors, small molecules, and biologics with potential anti-psoriatic properties was possible with the vast understanding of the pathogenesis of psoriasis. Various signalling pathways, including NF-κB, JAK-STAT, S1P, PDE-4, and A3AR that are involved in the pathogenesis of psoriasis as well as the preclinical models utilised in the research of psoriasis have been highlighted in this review. The review also focuses on technological advancements that have contributed to a better understanding of psoriasis. Then, the molecules targeting the respective signalling pathways that are still under clinical trials or recently approved as well as the latest breakthroughs in therapeutic and drug delivery approaches that can contribute to the improvement in the management of psoriasis are highlighted in this review. This review provides an extensive understanding of the current state of research in psoriasis, giving rise to opportunities for researchers to discover future therapeutic breakthroughs and personalised interventions. Efficient treatment options for individuals with psoriasis can be achieved by an extensive understanding of pathogenesis, therapeutic agents, and novel drug delivery strategies.
银屑病是一种影响全球约 2%-3%人口的慢性炎症性疾病。银屑病的发病机制复杂，涉及免疫失调、过度增殖和血管生成。它是一种多因素疾病，受遗传和环境因素的影响。随着对银屑病发病机制的深入了解，各种治疗药物的发展成为可能，如 JAK 抑制剂、小分子和具有潜在抗银屑病特性的生物制剂。本综述强调了涉及银屑病发病机制的各种信号通路，包括 NF-κB、JAK-STAT、S1P、PDE-4 和 A3AR，以及在银屑病研究中使用的临床前模型。该综述还重点介绍了有助于更好地了解银屑病的技术进步。然后，本文重点介绍了针对各自信号通路的分子，这些分子仍处于临床试验阶段或最近已获得批准，以及治疗和药物输送方法的最新突破，这些突破有助于改善银屑病的管理。本综述提供了对银屑病当前研究状况的广泛了解，为研究人员提供了发现未来治疗突破和个性化干预的机会。通过广泛了解发病机制、治疗药物和新型药物输送策略，可以为银屑病患者提供有效的治疗选择。
