Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA; University of Michigan Geriatrics Center, Ann Arbor, MI, USA.
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA; University of Michigan Geriatrics Center, Ann Arbor, MI, USA.
Free Radic Biol Med. 2024 Nov 1;224:246-255. doi: 10.1016/j.freeradbiomed.2024.08.018. Epub 2024 Aug 15.
Oxidative metabolism declines with aging in humans leading to multiple metabolic ailments and subsequent inflammation. In mice, there is evidence of age-related suppression of fatty acid oxidation and oxidative phosphorylation in the liver, heart, and muscles. Many interventions that extend healthy lifespan of mice have been developed, including genetic, pharmacological, and dietary interventions. In this article, we review the literature on oxidative metabolism changes in response to those interventions. We also discuss the molecular pathways that mediate those changes, and their potential as targets for future longevity interventions.
随着人类年龄的增长，氧化代谢会下降，导致多种代谢疾病和随后的炎症。在小鼠中，有证据表明肝脏、心脏和肌肉中的脂肪酸氧化和氧化磷酸化与年龄相关。已经开发出许多延长小鼠健康寿命的干预措施，包括遗传、药理学和饮食干预。在本文中，我们回顾了针对这些干预措施的氧化代谢变化的文献。我们还讨论了介导这些变化的分子途径及其作为未来长寿干预靶点的潜力。
