College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China; Xinjiang Key Laboratory of Clinical Drug Research, Urumqi 830011, China.
Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China; Xinjiang Key Laboratory of Clinical Drug Research, Urumqi 830011, China.
Int J Biol Macromol. 2024 Oct;278(Pt 2):134786. doi: 10.1016/j.ijbiomac.2024.134786. Epub 2024 Aug 15.
Cistanche deserticola Y. C. Ma (CD), is mainly distributed in the regions of China (Xinjiang, Inner Mongolia, Gansu), Mongolia, Iran and India. Cistanche deserticola polysaccharide (CDPs), as one of the main components and a crucial bioactive substance of CD, has a variety of pharmacological activities, including immunomodulatory, anti-aging, anti-oxidant, hepatoprotective, anti-osteoporotic, anti-inflammatory, intestinal flora regulatory effects. Many polysaccharides have been successfully obtained in the last three decades from CD. However, there is currently no comprehensive review available concerning CDPs. Considering the importance of CDPs for biological study and drug discovery, the present review aims to systematically summarize the recent major studies on extraction and purification methods of polysaccharides from CD, as well as the characterization of their chemical structure, biological activity, structure-activity relationship, and the application of CDPs in pharmaceutical field. Meanwhile, the shortcomings of CDPs research are further discussed in detail, and new valuable insights for future CDPs research as therapeutic agents and functional foods are proposed.
肉苁蓉（Cistanche deserticola Y. C. Ma）主要分布在中国（新疆、内蒙古、甘肃）、蒙古、伊朗和印度地区。肉苁蓉多糖（CDPs）作为肉苁蓉的主要成分之一和关键的生物活性物质，具有多种药理活性，包括免疫调节、抗衰老、抗氧化、保肝、抗骨质疏松、抗炎、调节肠道菌群等作用。在过去的三十年中，已经成功地从肉苁蓉中获得了多种多糖。然而，目前还没有关于 CDPs 的全面综述。鉴于 CDPs 对生物研究和药物发现的重要性，本综述旨在系统总结近年来从肉苁蓉中提取和纯化多糖的主要研究进展，以及其化学结构、生物活性、构效关系的表征，以及 CDPs 在药物领域的应用。同时，还详细讨论了 CDPs 研究的不足之处，并为未来作为治疗剂和功能性食品的 CDPs 研究提出了新的有价值的见解。
