口腔黏膜炎屏障保护剂早期干预慢性口腔移植物抗宿主病：一项回顾性队列研究。
Early intervention with oral mucosal barrier Protective agents in chronic oral graft-versus-host disease: a retrospective cohort study.
机构信息
Department of Hematology, Nanfang Hospital, 1838 North Guangzhou Avenue, Baiyun District, Guangzhou City, Guangdong Province, China.
出版信息
BMC Oral Health. 2024 Aug 17;24(1):958. doi: 10.1186/s12903-024-04724-6.
BACKGROUND
Preventing the progression of chronic oral graft-versus-host disease (cGVHD) is essential for maintaining oral health, improving quality of life, minimizing functional impairment, reducing systemic complications, and addressing treatment challenges.
PURPOSE
To evaluate the effectiveness of early intervention with oral mucosal barrier protective agents in preventing the progression of cGVHD and its impact on oral health, quality of life, and treatment response.
METHODS
This retrospective cohort study included 75 participants, with 34 in the non-oral mucosal barrier protective agent group and 41 in the oral mucosal barrier protective agent group. Baseline characteristics, oral mucosal health parameters, quality of life assessments, and curative effect data were collected and compared between the two study groups.
RESULTS
The group receiving oral mucosal barrier protectants (n = 41) exhibited significantly lower severity of oral mucositis compared to the group without such protectants (n = 34) (2.12 ± 0.48 vs. 2.56 ± 0.63, P = 0.001) and the incidence of complications was significantly lower in the group receiving oral mucosal barrier protectants (P < 0.05). Additionally, the quality of life assessment showed marked improvements in somatization, emotional management, and social reintegration in the oral mucosal barrier protectant group compared to the group without these protectants (P < 0.05). Furthermore, the assessment of treatment efficacy revealed significantly higher rates of both complete and partial responses in the oral mucosal barrier protectant group, along with a notable reduction in disease progression compared to the group without these protectants (P < 0.001).
CONCLUSION
Early intervention with oral mucosal barrier protective agents was associated with improved oral health parameters, enhanced quality of life, and a more favorable treatment response in the context of cGVHD.
背景
预防慢性口腔移植物抗宿主病（cGVHD）的进展对于维持口腔健康、提高生活质量、最大限度减少功能障碍、降低全身并发症发生率以及解决治疗挑战至关重要。
目的
评估口腔黏膜屏障保护剂早期干预预防 cGVHD 进展的效果及其对口腔健康、生活质量和治疗反应的影响。
方法
本回顾性队列研究纳入 75 名参与者，其中 34 名未使用口腔黏膜屏障保护剂，41 名使用口腔黏膜屏障保护剂。收集并比较两组患者的基线特征、口腔黏膜健康参数、生活质量评估和疗效数据。
结果
使用口腔黏膜屏障保护剂组（n=41）的口腔黏膜炎严重程度明显低于未使用组（n=34）（2.12±0.48 比 2.56±0.63，P=0.001），且使用口腔黏膜屏障保护剂组的并发症发生率也明显更低（P<0.05）。此外，口腔黏膜屏障保护剂组的躯体化、情绪管理和社会再融入的生活质量评估较未使用组显著改善（P<0.05）。另外，治疗效果评估显示，口腔黏膜屏障保护剂组的完全缓解和部分缓解率均明显更高，疾病进展明显减少，与未使用组相比差异有统计学意义（P<0.001）。
结论
在 cGVHD 患者中，早期应用口腔黏膜屏障保护剂可改善口腔健康参数、提高生活质量，并对治疗反应产生有利影响。
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