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797 个来自早期山羊瘤胃的宏基因组组装基因组。

Seven hundred and ninety-seven metagenome-assembled genomes from the goat rumen during early life.

机构信息

Key Laboratory of Feed Biotechnology of the Ministry of Agriculture, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.

出版信息

Sci Data. 2024 Aug 17;11(1):897. doi: 10.1038/s41597-024-03703-4.

DOI:10.1038/s41597-024-03703-4
PMID:39154041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11330487/
Abstract

The rumen microbiome plays an important role in providing energy and protein to the host. Manipulation of rumen microbiome during early life may have a long-term beneficial effect on the health, growth performance, and feed efficiency of ruminants. To better understand the profiles and functional potentials of rumen microbiome in young ruminants, metagenomic binning was performed to investigate the rumen microbiome of goat kids from one to 84 days of age. A total of 797 metagenome-assembled genomes (MAGs) were recovered from the rumen of 42 Laiwu black goat kids. Our findings provide fundamental knowledge of the rumen microbiome during early life based on metagenomic binning, which may provide insights into effective strategies to achieve long-term beneficial effects on animal health and production.

摘要

瘤胃微生物组在为宿主提供能量和蛋白质方面发挥着重要作用。在生命早期对瘤胃微生物组进行操纵可能对反刍动物的健康、生长性能和饲料效率产生长期的有益影响。为了更好地了解幼龄反刍动物瘤胃微生物组的特征和功能潜力,本研究通过宏基因组binning 分析了 1-84 日龄莱芜黑山羊羔羊的瘤胃微生物组。从 42 只莱芜黑山羊羔羊的瘤胃中总共回收了 797 个宏基因组组装基因组(MAG)。我们的研究结果为基于宏基因组 binning 的生命早期瘤胃微生物组提供了基础的知识,这可能为实现对动物健康和生产的长期有益影响的有效策略提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a2/11330487/65322fe82c04/41597_2024_3703_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a2/11330487/65322fe82c04/41597_2024_3703_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a2/11330487/65322fe82c04/41597_2024_3703_Fig1_HTML.jpg

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本文引用的文献

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Microbiome. 2024 Jan 22;12(1):14. doi: 10.1186/s40168-023-01733-5.
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A comparison of single-coverage and multi-coverage metagenomic binning reveals extensive hidden contamination.单覆盖度与多覆盖度宏基因组 bin 划分比较揭示了广泛存在的隐藏污染。
Nat Methods. 2023 Aug;20(8):1170-1173. doi: 10.1038/s41592-023-01934-8. Epub 2023 Jun 29.
3
Investigation of fiber utilization in the rumen of dairy cows based on metagenome-assembled genomes and single-cell RNA sequencing.
基于宏基因组组装基因组和单细胞 RNA 测序研究奶牛瘤胃中的纤维利用。
Microbiome. 2022 Jan 20;10(1):11. doi: 10.1186/s40168-021-01211-w.
4
A review of computational tools for generating metagenome-assembled genomes from metagenomic sequencing data.从宏基因组测序数据生成宏基因组组装基因组的计算工具综述。
Comput Struct Biotechnol J. 2021 Nov 23;19:6301-6314. doi: 10.1016/j.csbj.2021.11.028. eCollection 2021.
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How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?早期生命肠道微生物群的改变如何设定健康和炎症性肠病的发展轨迹?
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