Dermatology and Venerology Clinic, Zonguldak Atatürk State Hospital, Zonguldak, Turkey.
Department of Dermatology and Venerology, Koç University Medical Faculty, Istanbul, Turkey.
Arch Dermatol Res. 2024 Aug 17;316(8):533. doi: 10.1007/s00403-024-03334-0.
The circulating androgens have a role in the pathogenesis of both acne vulgaris and androgenetic alopecia; an association between these two have been found previously. The aim of this study is to investigate the relationship of the severity of acne vulgaris lesions to the subtype of AGA; and to validate the relationship between severities of acne vulgaris and AGA. This study was conducted cross-sectionally at five different dermatology clinics. Male and female androgenetic alopecia patients with comorbid acne vulgaris have been included. The age, gender, severity of acne lesions, subtype of androgenetic alopecia and the severity of androgenetic alopecia were noted. The severity of acne lesions were graded according to the Global Acne Severity Scale and androgenetic alopecia was graded according to the Hamilton and Ludwig Scales. SPSS v 21 was used for the statistical analysis. A total of 101 patients have been included (12 male and 89 female). The mean age of the patients with severe acne was statistically significantly lower (p = 0.020). The difference in terms of gender was statistically insignificant (p = 0.388). The severity of acne vulgaris was found to be independent of the severity and of the subtype of AGA; p = 0.623 and 0.870 respectively. Neither a relationship between the severity of androgenetic alopecia and severity of acne; nor a relationship between acne severity and androgenetic alopecia subtype were found in this study. Thus we report that, acne severity is independent of the subtype and stage of the co-existing androgenetic alopecia.
循环雄激素在寻常痤疮和雄激素性脱发的发病机制中都有作用；先前已经发现这两种疾病之间存在关联。本研究旨在探讨寻常痤疮皮损严重程度与 AGA 亚型的关系；并验证寻常痤疮和 AGA 严重程度之间的关系。本研究在五个不同的皮肤科诊所进行了横断面研究。纳入了患有寻常痤疮合并雄激素性脱发的男性和女性患者。记录了年龄、性别、痤疮皮损严重程度、雄激素性脱发亚型和雄激素性脱发严重程度。根据全球痤疮严重程度量表对痤疮皮损严重程度进行分级，根据 Hamilton 和 Ludwig 量表对雄激素性脱发进行分级。使用 SPSS v 21 进行统计分析。共纳入 101 例患者（男性 12 例，女性 89 例）。严重痤疮患者的平均年龄具有统计学意义（p=0.020）。性别差异无统计学意义（p=0.388）。寻常痤疮的严重程度与 AGA 的严重程度和亚型无关；分别为 p=0.623 和 0.870。本研究未发现雄激素性脱发严重程度与痤疮严重程度之间的关系，也未发现痤疮严重程度与雄激素性脱发亚型之间的关系。因此，我们报告说，痤疮严重程度与共存的雄激素性脱发的亚型和阶段无关。
