Executive Dentistry Clinics Rehman Medical Institute, Peshawar, Pakistan.
Operative Dentistry & Endodontics, Department of Surgery, Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan.
BMC Oral Health. 2024 Aug 17;24(1):961. doi: 10.1186/s12903-024-04709-5.
Parameningeal rhabdomyosarcoma (PM-RMS) is a rare and aggressive soft tissue malignancy that primarily occurs in the head and neck region. The standard treatment approach for RMS involves a multimodal therapy regimen, which includes surgery, chemotherapy, and radiotherapy. However, the routine use of radiotherapy and chemotherapy in young patients with RMS in the head and neck region can lead to adverse effects on dental development and thereby, pose a challenge in planning dental intervention.
This case report outlines the dental and facial developmental consequences in a 13-year-old child, who received chemo-radiotherapeutic intervention at the age of 7 years for the management of PM-RMS. Following treatment, the child exhibited significant dental complications, including arrested root growth and restricted mouth opening.
This case highlights the necessity for interdisciplinary collaboration between oncologists, dentists, and other healthcare professionals to mitigate the adverse effects on dental health and overall quality of life in patients undergoing chemo-radiotherapy for rhabdomyosarcoma.
脑脊膜旁横纹肌肉瘤(PM-RMS)是一种罕见且侵袭性的软组织恶性肿瘤,主要发生在头颈部。RMS 的标准治疗方法包括多模式治疗方案,包括手术、化疗和放疗。然而,在头颈部 RMS 的年轻患者中常规使用放疗和化疗会对牙齿发育产生不良影响,从而在计划牙科干预时带来挑战。
本病例报告概述了一名 13 岁儿童的牙齿和面部发育后果,该儿童在 7 岁时因 PM-RMS 接受化疗和放疗干预。治疗后,患儿出现严重的牙齿并发症,包括牙根生长停滞和张口受限。
本病例强调了肿瘤学家、牙医和其他医疗保健专业人员之间进行跨学科合作的必要性,以减轻接受横纹肌肉瘤化疗和放疗的患者的牙齿健康和整体生活质量的不良影响。