An effective procedure used metal-organic framework for determination of cadmium ions in real tap water and human blood plasma samples.

A newly developed 2H5MA-MOF sensor by covalently linking NH-MIL-53(Al) with 2'-Hydroxy-5'-methylacetophenon, designed for highly sensitive and selective detection of Cd ions using fluorometric methods. Detailed structural and morphological analyses confirmed the sensor's unique properties. It demonstrated an impressive linear detection range from 0 to 2 ppm, with an exceptionally low detection limit of 5.77 × 10 ppm and a quantification limit of 1.75 × 10 ppm, indicating its high sensitivity (R = 0.9996). The sensor also responded quickly, detecting Cd within just 30 s at pH 4. We successfully tested it on real samples of tap water and human blood plasma, achieving recovery rates between 96 % and 104 %. The accuracy of these findings was further validated by comparison with ICP-OES. Overall, the 2H5MA-MOF sensor shows great potential for fast, ultra-sensitive, and reliable detection of Cd ions, making it a promising tool for environmental and biomedical applications.